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Journal Articles Drug Discovery Today Year : 2006

Therapeutic potential of interfering with apelin signalling.


The apelin receptor is a G protein-coupled receptor activated by several apelin fragments. Its tissue distribution suggests that apelin signalling is involved in a broad range of physiological functions. Endothelial cells, which express high levels of apelin receptors, respond to apelin through the phosphorylation of key intracellular effectors associated with cell proliferation and migration. In addition, apelin is a mitogen for endothelial cells and exhibits angiogenic properties in matrigel experiments. This review focuses on the therapeutic potential of apelin signalling, which is associated with pathologies that result from decreased vascularisation (ischemias) or neovascularisation (retinopathies and solid tumors).

Dates and versions

inserm-00481028 , version 1 (05-05-2010)



S Caroline Sorli, Loïc van den Berghe, Bernard Masri, Bernard Knibiehler, Yves Audigier. Therapeutic potential of interfering with apelin signalling.. Drug Discovery Today, 2006, 11 (23-24), pp.1100-6. ⟨10.1016/j.drudis.2006.10.011⟩. ⟨inserm-00481028⟩
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