Skip to Main content Skip to Navigation
Journal articles

Therapeutic potential of interfering with apelin signalling.

Abstract : The apelin receptor is a G protein-coupled receptor activated by several apelin fragments. Its tissue distribution suggests that apelin signalling is involved in a broad range of physiological functions. Endothelial cells, which express high levels of apelin receptors, respond to apelin through the phosphorylation of key intracellular effectors associated with cell proliferation and migration. In addition, apelin is a mitogen for endothelial cells and exhibits angiogenic properties in matrigel experiments. This review focuses on the therapeutic potential of apelin signalling, which is associated with pathologies that result from decreased vascularisation (ischemias) or neovascularisation (retinopathies and solid tumors).
Document type :
Journal articles
Complete list of metadata
Contributor : Marie Francoise Simon Connect in order to contact the contributor
Submitted on : Wednesday, May 5, 2010 - 5:16:50 PM
Last modification on : Wednesday, June 1, 2022 - 3:59:24 AM

Links full text




S Caroline Sorli, Loïc van den Berghe, Bernard Masri, Bernard Knibiehler, yves Audigier. Therapeutic potential of interfering with apelin signalling.. Drug Discovery Today, Elsevier, 2006, 11 (23-24), pp.1100-6. ⟨10.1016/j.drudis.2006.10.011⟩. ⟨inserm-00481028⟩



Record views