Therapeutic potential of interfering with apelin signalling.

S Caroline Sorli 1 Loïc Van den Berghe 1 Bernard Masri 1 Bernard Knibiehler 1 Yves Audigier 1, *
* Auteur correspondant
1 Hormones, facteurs de croissance et physiopathologie vasculaire
Abstract : The apelin receptor is a G protein-coupled receptor activated by several apelin fragments. Its tissue distribution suggests that apelin signalling is involved in a broad range of physiological functions. Endothelial cells, which express high levels of apelin receptors, respond to apelin through the phosphorylation of key intracellular effectors associated with cell proliferation and migration. In addition, apelin is a mitogen for endothelial cells and exhibits angiogenic properties in matrigel experiments. This review focuses on the therapeutic potential of apelin signalling, which is associated with pathologies that result from decreased vascularisation (ischemias) or neovascularisation (retinopathies and solid tumors).
Type de document :
Article dans une revue
Drug Discovery Today, Elsevier, 2006, 11 (23-24), pp.1100-6. 〈10.1016/j.drudis.2006.10.011〉
Liste complète des métadonnées
http://www.hal.inserm.fr/inserm-00481028
Contributeur : Marie Francoise Simon <>
Soumis le : mercredi 5 mai 2010 - 17:16:50
Dernière modification le : vendredi 14 septembre 2018 - 01:00:34

Identifiants

Collections

UNIV-TLSE3

Citation

S Caroline Sorli, Loïc Van den Berghe, Bernard Masri, Bernard Knibiehler, Yves Audigier. Therapeutic potential of interfering with apelin signalling.. Drug Discovery Today, Elsevier, 2006, 11 (23-24), pp.1100-6. 〈10.1016/j.drudis.2006.10.011〉. 〈inserm-00481028〉

Exporter

BibTeX TEI DC DCterms EndNote

Partager

Métriques

Consultations de la notice

89

Contact

support.ccsd.cnrs.fr
hal.support@ccsd.cnrs.fr
Logo CCSD