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Pulmonary and cutaneous sarcoidosis associated with interferon therapy for melanoma.

Fabien Pelletier 1 Philippe Manzoni 1 Pascale Jacoulet 1, 2 Philippe Humbert 3 François Aubin 1, 2
1 Département de dermatologie
2 CEF2P / CARCINO - Carcinogénèse épithéliale : facteurs prédictifs et pronostiques - UFC (EA 3181)
3 HOTE GREFFON - Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098)
Abstract : Interferon alfa is widely used as adjuvant therapy for melanoma. Numerous side effects have been attributed to interferon alfa. Interferon alfa-induced sarcoidosis is an uncommon event. We report the third case of pulmonary and cutaneous sarcoidosis in the course of interferon alfa treatment for melanoma. Most cases of sarcoidosis have been reported during treatment of chronic hepatitis C. The prognosis is good with discontinuation of treatment. Other than interferon therapy, sarcoidosis or granulomatosis reactions rarely have been reported in malignant melanoma. We discuss and review the literature on the physiopathology of sarcoidosis brought on by interferon therapy.
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https://www.hal.inserm.fr/inserm-00479746
Contributor : Philippe Saas <>
Submitted on : Sunday, May 23, 2010 - 1:16:52 PM
Last modification on : Wednesday, September 16, 2020 - 2:20:04 PM

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  • HAL Id : inserm-00479746, version 1
  • PUBMED : 18189032

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UNIV-FCOMTE | UMR645

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Fabien Pelletier, Philippe Manzoni, Pascale Jacoulet, Philippe Humbert, François Aubin. Pulmonary and cutaneous sarcoidosis associated with interferon therapy for melanoma.. Cutis; cutaneous medicine for the practitioner, 2007, 80 (5), pp.441-5. ⟨inserm-00479746⟩

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