Hyperacute rejection after lung transplantation caused by undetected low-titer anti-HLA antibodies.

Abstract : Hyperacute rejection is an early complication of transplantation, caused by the presence in the recipient of pre-formed donor-directed antibodies (Ab). We report a case of fatal early graft dysfunction after lung transplantation in a female recipient with no anti-HLA Ab detected before transplantation. Further immunologic studies revealed the presence, in the pre-transplant serum, of low-titer anti-HLA Ab directed against the donor's HLA, detectable only by flow-cytometry screening for panel-reactive antibodies. This observation emphasizes the importance of sensitive Ab detection in patients awaiting lung transplantation. Women should be specifically targeted for such sensitive Ab detection.
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Article dans une revue
The Journal of Heart and Lung Transplantation, Elsevier, 2007, 26 (6), pp.642-5. 〈10.1016/j.healun.2007.03.007〉
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Contributeur : Philippe Saas <>
Soumis le : dimanche 2 mai 2010 - 12:33:21
Dernière modification le : lundi 9 juillet 2018 - 13:12:02

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Emeline Masson, Marc Stern, Jacqueline Chabod, Chantal Thévenin, François Gonin, et al.. Hyperacute rejection after lung transplantation caused by undetected low-titer anti-HLA antibodies.. The Journal of Heart and Lung Transplantation, Elsevier, 2007, 26 (6), pp.642-5. 〈10.1016/j.healun.2007.03.007〉. 〈inserm-00479709〉

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