Hyperacute rejection after lung transplantation caused by undetected low-titer anti-HLA antibodies.

Emeline Masson; Marc Stern; Jacqueline Chabod; Chantal Thévenin; François Gonin; Jean-Michel Rebibou; Pierre Tiberghien

doi:10.1016/j.healun.2007.03.007

Hyperacute rejection after lung transplantation caused by undetected low-titer anti-HLA antibodies.

Emeline Masson ^{1, 2} Marc Stern ³ Jacqueline Chabod ² Chantal Thévenin ² François Gonin ³ Jean-Michel Rebibou ^{1, 4} Pierre Tiberghien ^{1, 2}

1 HOTE GREFFON - Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098)

2 Laboratoire d'Immunogénétique

3 Unité de Transplantation Pulmonaire

4 Service de Néphrologie et Urologie

Abstract : Hyperacute rejection is an early complication of transplantation, caused by the presence in the recipient of pre-formed donor-directed antibodies (Ab). We report a case of fatal early graft dysfunction after lung transplantation in a female recipient with no anti-HLA Ab detected before transplantation. Further immunologic studies revealed the presence, in the pre-transplant serum, of low-titer anti-HLA Ab directed against the donor's HLA, detectable only by flow-cytometry screening for panel-reactive antibodies. This observation emphasizes the importance of sensitive Ab detection in patients awaiting lung transplantation. Women should be specifically targeted for such sensitive Ab detection.

Type de document :

Article dans une revue

The Journal of Heart and Lung Transplantation, Elsevier, 2007, 26 (6), pp.642-5. 〈10.1016/j.healun.2007.03.007〉

Domaine :

Sciences du Vivant [q-bio] / Immunologie

Liste complète des métadonnées

http://www.hal.inserm.fr/inserm-00479709
Contributeur : Philippe Saas <>
Soumis le : dimanche 2 mai 2010 - 12:33:21
Dernière modification le : lundi 9 juillet 2018 - 13:12:02

Hyperacute rejection after lung transplantation caused by undetected low-titer anti-HLA antibodies.

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Hyperacute rejection after lung transplantation caused by undetected low-titer anti-HLA antibodies.

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