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Hyperacute rejection after lung transplantation caused by undetected low-titer anti-HLA antibodies.

Emeline Masson 1, 2 Marc Stern 3 Jacqueline Chabod 2 Chantal Thévenin 2 François Gonin 3 Jean-Michel Rebibou 1, 4 Pierre Tiberghien 1, 2
1 RIGHT - Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098)
2 Laboratoire d'Immunogénétique
3 Unité de Transplantation Pulmonaire
4 Service d'urologie, andrologie et transplantation rénale
Abstract : Hyperacute rejection is an early complication of transplantation, caused by the presence in the recipient of pre-formed donor-directed antibodies (Ab). We report a case of fatal early graft dysfunction after lung transplantation in a female recipient with no anti-HLA Ab detected before transplantation. Further immunologic studies revealed the presence, in the pre-transplant serum, of low-titer anti-HLA Ab directed against the donor's HLA, detectable only by flow-cytometry screening for panel-reactive antibodies. This observation emphasizes the importance of sensitive Ab detection in patients awaiting lung transplantation. Women should be specifically targeted for such sensitive Ab detection.
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https://www.hal.inserm.fr/inserm-00479709
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Submitted on : Sunday, May 2, 2010 - 12:33:21 PM
Last modification on : Tuesday, October 27, 2020 - 2:35:49 PM

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UNIV-FCOMTE | UMR645

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Emeline Masson, Marc Stern, Jacqueline Chabod, Chantal Thévenin, François Gonin, et al.. Hyperacute rejection after lung transplantation caused by undetected low-titer anti-HLA antibodies.. The Journal of Heart and Lung Transplantation, Elsevier, 2007, 26 (6), pp.642-5. ⟨10.1016/j.healun.2007.03.007⟩. ⟨inserm-00479709⟩

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