The inducible T-cell co-stimulator molecule is expressed on subsets of T cells and is a new marker of lymphomas of T follicular helper cell-derivation.

Teresa Marafioti 1, * Jennifer Paterson 1 Erica Ballabio 1 Andreas Chott 2 Yasodha Natkunam 3 Manuel Rodriguez-Justo 4 Anne Plonquet 5, 6 Socorro Rodriguez-Pinilla 7 Wolfram Klapper 8 Martin-L Hansmann 9 Stefano Pileri 10 Peter Isaacson 4 Harald Stein 11 Miguel Piris 7 David Mason 12 Philippe Gaulard 6, 13
* Auteur correspondant
1 Leukaemia Research Immunodiagnostics Unit
2 Departement of Pathology
3 Department of Pathology [Stanford]
4 Department of Histopathology
5 Service d'immunologie biologique
6 IMRB - Institut Mondor de Recherche Biomédicale
7 Molecular Pathology Programme
8 Department of Hematopathology
9 Department of Pathology
10 Department of Haematology and Clinical Oncology
11 Institute of Pathology
12 University of Delaware [Newark]
13 Département de pathologie [Mondor]
Abstract : BACKGROUND: T follicular helper (T(FH)) cells reside in the light zone of germinal centers and are considered the cell of origin of angioimmunoblastic T-cell lymphoma. Recently, CXCL13, PD-1 and SAP were described as useful markers for T(FH) cells and angioimmunoblastic T-cell lymphoma but also reported in some peripheral T-cell lymphomas, not otherwise specified. DESIGN AND METHODS: In the present study the expression pattern of ICOS protein was investigated by immunohistochemistry-based techniques in routine sections of normal lymphoid tissues and 633 human lymphomas. RESULTS: Cells strongly positive for ICOS were restricted to the light zone of germinal centers and co-expressed T(FH)-associated molecules. In addition, weak to moderate ICOS expression was observed in a small proportion of FOXP3-positive cells. In lymphomas, ICOS expression was confined to angioimmunoblastic T-cell lymphoma (85/86), peripheral T-cell lymphomas of follicular variant (18/18) and a proportion of peripheral T-cell lymphomas, not otherwise specified (24/56) that also expressed other T(FH)-associated molecules. CONCLUSIONS: ICOS is a useful molecule for identifying T(FH) cells and its restricted expression to angioimmunoblastic T-cell lymphoma and a proportion of peripheral T-cell lymphomas, not otherwise specified (showing a T(FH)-like profile) suggests its inclusion in the antibody panel for diagnosing T(FH)-derived lymphomas. Our findings provide further evidence that the histological spectrum of T(FH)-derived lymphomas is broader than previously assumed.
Keywords : ICOS TFH cells angioimmunoblastic T-cell lymphoma
Type de document :
Article dans une revue
Haematologica, Ferrata Storti Foundation, 2010, 95 (3), pp.432-9. 〈10.3324/haematol.2009.010991〉
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Soumis le : jeudi 29 avril 2010 - 14:07:50
Dernière modification le : lundi 19 mars 2018 - 10:00:14
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Teresa Marafioti, Jennifer Paterson, Erica Ballabio, Andreas Chott, Yasodha Natkunam, et al.. The inducible T-cell co-stimulator molecule is expressed on subsets of T cells and is a new marker of lymphomas of T follicular helper cell-derivation.. Haematologica, Ferrata Storti Foundation, 2010, 95 (3), pp.432-9. 〈10.3324/haematol.2009.010991〉. 〈inserm-00477518〉

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