A. Jemal, R. Siegel, E. Ward, T. Murray, J. Xu et al., Cancer Statistics, 2007, Cancer statistics, pp.43-66, 2007.
DOI : 10.3322/canjclin.57.1.43

S. Lam, T. Kennedy, M. Unger, Y. Miller, D. Gelmont et al., Localization of Bronchial Intraepithelial Neoplastic Lesions by Fluorescence Bronchoscopy, Chest, vol.113, issue.3, pp.696-702, 1998.
DOI : 10.1378/chest.113.3.696

T. Kennedy, F. Hirsch, Y. Miller, S. Prindiville, J. Murphy et al., A randomized study of fluorescence bronchoscopy versus white-light bronchoscopy for early detection of lung cancer in high risk patients, Lung Cancer, vol.29, issue.1, p.835, 2000.
DOI : 10.1016/S0169-5002(00)80835-1

C. Paris, J. Benichou, S. Bota, S. Sagnier, J. Mé-tayer et al., Occupational and nonoccupational factors associated with high grade bronchial pre-invasive lesions, European Respiratory Journal, vol.21, issue.2, pp.332-341, 2003.
DOI : 10.1183/09031936.03.00001503

S. Bota, J. Auliac, C. Paris, J. Mé-tayer, ´. R. Sesboü-e et al., Using Fluorescence Endoscopy, American Journal of Respiratory and Critical Care Medicine, vol.164, issue.9, pp.1688-1693, 2001.
DOI : 10.1164/ajrccm.164.9.2012147

R. Breuer, A. Pasic, E. Smit, V. Vliet, E. et al., The natural course of preneoplastic lesions in bronchial epithelium, Clin Cancer Res, vol.11, pp.537-543, 2005.

G. Auer, J. Ono, M. Nasiell, T. Caspersoon, H. Kato et al., Reversibility of bronchial cell atypia, Cancer Res, vol.42, pp.4241-4247, 1982.

O. Auerbach, A. Stout, E. Hammond, and L. Garfinkel, Changes in Bronchial Epithelium in Relation to Cigarette Smoking and in Relation to Lung Cancer, New England Journal of Medicine, vol.265, issue.6, pp.253-267, 1961.
DOI : 10.1056/NEJM196108102650601

S. Lam, J. Le-riche, Y. Zheng, A. Coldman, C. Macaulay et al., Sex-Related Differences in Bronchial Epithelial Changes Associated With Tobacco Smoking, JNCI Journal of the National Cancer Institute, vol.91, issue.8, pp.691-696, 1999.
DOI : 10.1093/jnci/91.8.691

G. Loewen, N. Natarajan, D. Tan, E. Nava, D. Klippenstein et al., Autofluorescence bronchoscopy for lung cancer surveillance based on risk assessment, Thorax, vol.62, issue.4, pp.335-340, 2007.
DOI : 10.1136/thx.2006.068999

P. George, A. Banerjee, C. Read, O. Sullivan, C. Falzon et al., Surveillance for the detection of early lung cancer in patients with bronchial dysplasia, Thorax, vol.62, issue.1, pp.43-50, 2007.
DOI : 10.1136/thx.2005.052191

L. Thiberville, P. Payne, J. Vielkinds, J. Leriche, D. Horsman et al., Evidence of cumulative gene losses with progression of premalignant epithelial lesions to carcinoma of the bronchus, Cancer Res, vol.55, pp.5133-5139, 1995.

E. Brambilla, S. Gazzeri, S. Lantuejoul, J. Coll, D. Moro et al., p53 mutant immunophenotype and deregulation of p53 transcription pathway (Bcl2, Bax, and Waf1) in precursor bronchial lesions of lung cancer, Clin Cancer Res, vol.4, pp.1609-1618, 1998.

E. Brambilla, S. Gazzeri, D. Moro, S. Lantuejoul, S. Veyrenc et al., Alterations of Rb pathway (Rb-p16INK4-Cyclin D1) in preinvasive bronchial lesions, Clin Cancer Res, vol.5, pp.243-250, 1999.

W. Westra, R. Slebos, G. Offerhaus, S. Goodman, S. Evers et al., K-ras oncogene activation in lung adenocarcinomas from former smokers evidence that K-ras mutations are an early and irreversible event in the development of adenocarcinoma of the lung, Cancer, vol.256, issue.2, pp.432-438, 1993.
DOI : 10.1002/1097-0142(19930715)72:2<432::AID-CNCR2820720219>3.0.CO;2-#

S. Gazzeri, E. Brambilla, C. De-fromentel, C. Gouyer, V. Moro et al., p53 genetic abnormalities andmyc activation in human lung carcinoma, International Journal of Cancer, vol.1, issue.1, pp.24-32, 1994.
DOI : 10.1002/ijc.2910580106

W. Rom, J. Hay, T. Lee, Y. Jiang, and K. Tchou-wong, Molecular and Genetic Aspects of Lung Cancer, American Journal of Respiratory and Critical Care Medicine, vol.161, issue.4, pp.1355-1367, 2000.
DOI : 10.1164/ajrccm.161.4.9908012

I. Wistuba, C. Behrens, S. Milchgrub, D. Bryant, J. Hung et al., Sequential molecular abnormalities are involved in the multistage development of squamous cell lung carcinoma, Oncogene, vol.18, issue.3, pp.643-650, 1999.
DOI : 10.1038/sj.onc.1202349

V. Sundaresan, P. Ganly, P. Hasleton, R. Rudd, G. Sinha et al., p53 and chromosome 3 abnormalities, characteristics of malignant lung tumours, are detectable in preinvasive lesions of the bronchus, Oncogene, vol.7, pp.1989-1997, 1992.

J. Hung, Y. Kishimoto, K. Sugio, A. Virmani, D. Mcintire et al., Allele-Specific Chromosome 3p Deletions Occur at an Early Stage in the Pathogenesis of Lung Carcinoma, JAMA: The Journal of the American Medical Association, vol.273, issue.7, pp.558-563, 1995.
DOI : 10.1001/jama.1995.03520310056030

E. Brambilla, W. Travis, T. Colby, C. B. Shimosato, and Y. , The new World Health Organization classification of lung tumours, European Respiratory Journal, vol.18, issue.6, pp.1059-1068, 2001.
DOI : 10.1183/09031936.01.00275301

K. Schutze, H. Posl, and G. Lahr, Laser micromanipulation systems as universal tools in cellular and molecular biology and in medicine, Cell Mol Biol, vol.44, pp.735-746, 1998.

H. Ninomiya, K. Nomura, Y. Satoh, S. Okumura, K. Nakagawa et al., Genetic instability in lung cancer: concurrent analysis of chromosomal, mini- and microsatellite instability and loss of heterozygosity, British Journal of Cancer, vol.52, issue.10, pp.1485-1491, 2006.
DOI : 10.1038/sj.ejhg.5200403

N. Foster, A. Banerjee, J. Xian, I. Roberts, F. Pezella et al., Somatic genetic changes accompanying lung tumor development, Genes, Chromosomes and Cancer, vol.18, issue.1, pp.65-75, 2005.
DOI : 10.1002/gcc.20223

L. Mao, J. Lee, Y. Fan, J. Ro, J. Batsakis et al., Frequent microsatellite alterations at chromosomes 9p21 and 3p14 in oral premalignant lesions and their value in cancer risk assessment, Nature Medicine, vol.87, issue.6, pp.682-685, 1996.
DOI : 10.1001/jama.273.7.558

M. Rosin, X. Cheng, C. Poh, W. Lam, Y. Huang et al., Use of allelic loss to predict malignant risk for low-grade oral epithelial dysplasia, Clin Cancer Res, vol.6, pp.357-362, 2000.

O. Kujan, R. Oliver, R. L. Sozzi, G. Ribeiro, N. Woodwards et al., Fragile Histidine Triad Expression in Oral Squamous Cell Carcinoma and Precursor Lesions, Clinical Cancer Research, vol.12, issue.22, pp.6723-6729, 2006.
DOI : 10.1158/1078-0432.CCR-06-1475

B. Venmans, V. Boxem, T. Smit, E. Postmus, P. Sutedja et al., Outcome of Bronchial Carcinoma In Situ, Chest, vol.117, issue.6, pp.1572-1576, 2000.
DOI : 10.1378/chest.117.6.1572

A. Banerjee, H. Pamela, P. Rabbitts, J. George, L. Thiberville et al., Are all high-grade preinvasive lesions premalignant, and should they all be treated?, American Journal of Respiratory and Critical Care Medicine, vol.165, issue.10, pp.1452-1453, 2002.
DOI : 10.1164/ajrccm.165.10.165105

I. Wistuba, C. Behrens, A. Virmani, G. Mele, S. Milchgrub et al., High resolution chromosome 3p allelotyping of human lung cancer and preneoplastic/ preinvasive bronchial epithelium reveals multiple, discontinuous sites of 3p allele loss and three regions of frequent breakpoints, Cancer Res, vol.60, pp.1949-1960, 2000.

A. Killian, D. Fiore, F. , L. Pessot, F. Blanchard et al., A Simple Method for the Routine Detection of Somatic Quantitative Genetic Alterations in Colorectal Cancer, Gastroenterology, vol.132, issue.2, pp.645-653, 2007.
DOI : 10.1053/j.gastro.2006.12.006