Relation of the ischaemic substrate to left ventricular remodelling by cardiac magnetic resonance at 1.5 T in rabbits.

Nicolas Mansencal 1 Renaud Tissier 1 Jean-François Deux 2 Bijan Ghaleh 1 Nicolas Couvreur 1 Mario Rienzo 2 Pascal Guéret 3 Alain Rahmouni 2 Alain Berdeaux 1 Jérôme Garot 1, 3, *
* Auteur correspondant
1 IMRB - Institut Mondor de recherche biomédicale
2 Service d'imagerie médicale
3 Service de cardiologie
Abstract : OBJECTIVES: Contrast-enhanced cardiac magnetic resonance (CMR) for infarct sizing has been validated in large animals, but studies and follow-up are restricted. We sought to (1) validate CMR for assessment of myocardial area at risk (MAR) and infarct size (IS) in a rabbit model of reperfused myocardial infarction (MI); (2) analyse the relation between ischaemic substrates and subsequent left ventricular (LV) remodelling. METHODS: Experimental reperfused acute MI was induced in 16 rabbits. Ten animals underwent cross-registered cine and contrast-enhanced CMR and histopathology at day 3 for assessment of MAR and IS (group 1). The remaining six rabbits underwent serial CMR for the study of LV remodelling (group 2). RESULTS: In group 1, mean IS was 12.7 +/- 6.4% and 12.7 +/- 6.9% of total LV myocardial mass on CMR (late-enhancement technique) and histopathology (P = 0.52; r = 0.93). No significant difference occurred between CMR and histopathology for the calculation of MAR and IS/MAR ratio (P = 0.18 and P = 0.17), whereas correlations were strong (r = 0.92 and r = 0.95). In group 2, mean LV end-diastolic, end-systolic volumes and LV mass were significantly increased at 3 weeks compared with measurements at day 3 (P < 0.01). Significant correlations between initial IS and the increase in LV end-diastolic volume (r = 0.66) and the increase in LV mass (r = 0.48) were observed, as well as correlations between initial MAR and the increase in LV end-diastolic volume (r = 0.70) and the increase in LV mass (r = 0.37). CONCLUSIONS: Comprehensive CMR provides accurate assessment of IS and MAR in reperfused rabbit MI. Infarct size is closely related to LV remodelling. Through the infarct size/MAR ratio, this approach has great potential for assessing interventions aimed at cardioprotection.
Keywords : left ventricular remodelling
Type de document :
Article dans une revue
European Radiology, Springer Verlag, 2010, 20 (5), pp.1214-20. 〈10.1007/s00330-009-1660-7〉
Liste complète des métadonnées

Littérature citée [8 références]  Voir  Masquer  Télécharger
http://www.hal.inserm.fr/inserm-00476405
Contributeur : Georges Guellaen <>
Soumis le : lundi 26 avril 2010 - 13:02:58
Dernière modification le : mercredi 29 novembre 2017 - 09:30:42
Document(s) archivé(s) le : mardi 28 septembre 2010 - 13:32:08

Fichiers

Garot_Eur_Radiol_HAL.pdf
Fichiers produits par l'(les) auteur(s)

Identifiants

Collections

IMRB | UPEC | UPEC-UPEM

Citation

Nicolas Mansencal, Renaud Tissier, Jean-François Deux, Bijan Ghaleh, Nicolas Couvreur, et al.. Relation of the ischaemic substrate to left ventricular remodelling by cardiac magnetic resonance at 1.5 T in rabbits.. European Radiology, Springer Verlag, 2010, 20 (5), pp.1214-20. 〈10.1007/s00330-009-1660-7〉. 〈inserm-00476405〉

Exporter

BibTeX TEI DC DCterms EndNote

Partager

Métriques

Consultations de la notice

311

Téléchargements de fichiers

699

Contact

support.ccsd.cnrs.fr
hal.support@ccsd.cnrs.fr
Logo CCSD