Studies on antidiabetic agents. Synthesis and hypoglycemic activity of 5-[ 4-(pyridylalkoxy)benzyl -2, p.4 ,
Transcription regulation of peroxisomal fatty acyl-CoA oxidase and enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase in rat liver by peroxisome proliferators., Proceedings of the National Academy of Sciences, vol.83, issue.6, pp.1747-1751, 1986. ,
DOI : 10.1073/pnas.83.6.1747
Apolipoprotein A-IV Messenger Ribonucleic Acid Abundance Is Regulated in a Tissue-Specific Manner*, Endocrinology, vol.126, issue.4, pp.2153-2163, 1990. ,
DOI : 10.1210/endo-126-4-2153
Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators, Nature, vol.347, issue.6294, pp.645-650, 1990. ,
DOI : 10.1038/347645a0
Convergence of 9-cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptors, Nature, vol.358, issue.6389, pp.771-774, 1992. ,
DOI : 10.1038/358771a0
The mouse peroxisome proliferator activated receptor recognizes a response element in the 5 flanking sequence of the rat acyl CoA oxidase gene ?, Embo J, vol.11, pp.433-439, 1992. ,
Control of the peroxisomal beta-oxidation pathway by a novel family of nuclear hormone receptors ,
Targeted disruption of the alpha isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators., Molecular and Cellular Biology, vol.15, issue.6, pp.3012-3022, 1995. ,
DOI : 10.1128/MCB.15.6.3012
Diminished Hepatocellular Proliferation in Mice Humanized for the Nuclear Receptor Peroxisome Proliferator-Activated Receptor ??, Cancer Research, vol.64, issue.11, pp.3849-3854, 2004. ,
DOI : 10.1158/0008-5472.CAN-04-0322
Mechanism of Action of Fibrates on Lipid and Lipoprotein Metabolism, Circulation, vol.98, issue.19, pp.2088-2093, 1998. ,
DOI : 10.1161/01.CIR.98.19.2088
Peroxisome Proliferator-Activated Receptors and Atherogenesis: Regulators of Gene Expression in Vascular Cells, Circulation Research, vol.94, issue.9, pp.1168-1178, 2004. ,
DOI : 10.1161/01.RES.0000127122.22685.0A
Stimulation of adipogenesis in fibroblasts by PPAR??2, a lipid-activated transcription factor, Cell, vol.79, issue.7, pp.1147-1156, 1994. ,
DOI : 10.1016/0092-8674(94)90006-X
mPPAR gamma 2: tissue-specific regulator of an adipocyte enhancer., Genes & Development, vol.8, issue.10, pp.1224-1234, 1994. ,
DOI : 10.1101/gad.8.10.1224
An Antidiabetic Thiazolidinedione Is a High Affinity Ligand for Peroxisome Proliferator-activated Receptor ?? (PPAR??), Journal of Biological Chemistry, vol.270, issue.22, pp.12953-12956, 1995. ,
DOI : 10.1074/jbc.270.22.12953
Glycemic Durability of Rosiglitazone, Metformin, or Glyburide Monotherapy, New England Journal of Medicine, vol.355, issue.23, pp.2427-2443, 2006. ,
DOI : 10.1056/NEJMoa066224
Secondary prevention of macrovascular events in patients with type 2 diabetes in the PROactive Study (PROspective pioglitAzone 46 Novel selective small molecule agonists for peroxisome proliferator-activated receptor delta (PPARdelta)--synthesis and biological activity, Bioorg Med Chem Lett, vol.13, pp.1517-1521, 2003. ,
Novel Peroxisome Proliferator-activated Receptor (PPAR) ?? and PPAR?? Ligands Produce Distinct Biological Effects, Journal of Biological Chemistry, vol.274, issue.10, pp.6718-6725, 1999. ,
DOI : 10.1074/jbc.274.10.6718
PPAR?? regulates glucose metabolism and insulin sensitivity, Proceedings of the National Academy of Sciences, vol.103, issue.9, pp.3444-3449, 2006. ,
DOI : 10.1073/pnas.0511253103
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1413918
Peroxisome proliferator-activated receptor-?? induces insulin-induced gene-1 and suppresses hepatic lipogenesis in obese diabetic mice, Hepatology, vol.536, issue.2, pp.432-441, 2008. ,
DOI : 10.1002/hep.22334
A selective peroxisome proliferator-activated receptor ?? agonist promotes reverse cholesterol transport, Proceedings of the National Academy of Sciences, vol.98, issue.9, pp.5306-5311, 2001. ,
DOI : 10.1073/pnas.091021198
Peroxisome proliferator-activated receptor delta controls muscle development and oxidative capability, Faseb J, vol.17, pp.2299-2301, 2003. ,
Regulation of Muscle Fiber Type and Running Endurance by PPAR??, PLoS Biology, vol.98, issue.10, p.294, 2004. ,
DOI : 10.1371/journal.pbio.0020294.sv002
PPAR?? and PPAR?? dual agonists for the treatment of type 2 diabetes and the metabolic syndrome, Current Opinion in Pharmacology, vol.6, issue.6, pp.606-614, 2006. ,
DOI : 10.1016/j.coph.2006.06.009
Effect of the dual peroxisome proliferator-activated receptor-??/?? agonist aleglitazar on risk of cardiovascular disease in patients with type 2 diabetes (SYNCHRONY): a phase II, randomised, dose-ranging study, The Lancet, vol.374, issue.9684, pp.126-135, 2009. ,
DOI : 10.1016/S0140-6736(09)60870-9
Effects of peroxisome proliferator-activated receptor ??/?? agonists on HDL-cholesterol in vervet monkeys, The Journal of Lipid Research, vol.46, issue.5, pp.1009-1016, 2005. ,
DOI : 10.1194/jlr.M500002-JLR200