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Article Dans Une Revue Swiss Medical Weekly Année : 2006

Early lymphocyte development in bone marrow and thymus.

Résumé

Haematopoietic stem cells (HSCs), a very rare cell type in the bone marrow, are responsible for the life-long production of all cells of the blood including T and B cells. Until recently, it was thought that the differentiation of HSCs into the various haematopoietic cells was rather hierarchical in that differentiation along a given lineage was associated with a progressive loss of potential to give rise to other blood cell lineages. The recent development of very sensitive and quantitative in vitro assays, together with the identification of new progenitor subpopulations, has challenged this idea. Thus, lymphocyte progenitors can be shown to keep their developmental potential to give rise to myeloid, dendritic and NK cells until just prior to their final commitment stage. Here we review these new findings and concepts.

Domaines

Immunologie
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Dates et versions

inserm-00475387 , version 1 (21-04-2010)

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Citer

Antonius G Rolink, Steffen Massa, Gina Balciunaite, Rhodri Ceredig. Early lymphocyte development in bone marrow and thymus.. Swiss Medical Weekly, 2006, 136 (43-44), pp.679-83. ⟨10.2006/43/smw-11413⟩. ⟨inserm-00475387⟩

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