Hepatic arterial infusion of gemcitabine-oxaliplatin in a large metastasis from colon cancer. - Archive ouverte HAL Access content directly
Journal Articles World Journal of Gastroenterology Year : 2010

Hepatic arterial infusion of gemcitabine-oxaliplatin in a large metastasis from colon cancer.

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Abstract

Hepatic arterial infusion (HAI) of chemotherapy can be performed in cases of liver-confined metastatic disease, resulting in increased local drug concentrations. Here we report the case of a 61-year-old man who presented with an isolated large unresectable liver metastasis of colon cancer after failure of surgery and multiple administration of systemic chemotherapy. The patient was treated with a combination of gemcitabine and oxaliplatin using HAI. The tolerance was excellent and a radiological complete response was obtained after 8 cycles of HAI. The rationale for the use of gemcitabine and oxaliplatin as well as that for the combination of the 2 drugs is discussed in this paper. HAI of gemcitabine-oxaliplatin should be evaluated in further clinical trials.
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Dates and versions

inserm-00475002 , version 1 (21-04-2010)

Identifiers

  • HAL Id : inserm-00475002 , version 1
  • PUBMED : 20205288

Cite

Boris Guiu, Julie Vincent, Séverine Guiu, Sylvain Ladoire, Pablo Ortega-Deballon, et al.. Hepatic arterial infusion of gemcitabine-oxaliplatin in a large metastasis from colon cancer.. World Journal of Gastroenterology, 2010, 16 (9), pp.1150-4. ⟨inserm-00475002⟩
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