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Hepatic arterial infusion of gemcitabine-oxaliplatin in a large metastasis from colon cancer.

Abstract : Hepatic arterial infusion (HAI) of chemotherapy can be performed in cases of liver-confined metastatic disease, resulting in increased local drug concentrations. Here we report the case of a 61-year-old man who presented with an isolated large unresectable liver metastasis of colon cancer after failure of surgery and multiple administration of systemic chemotherapy. The patient was treated with a combination of gemcitabine and oxaliplatin using HAI. The tolerance was excellent and a radiological complete response was obtained after 8 cycles of HAI. The rationale for the use of gemcitabine and oxaliplatin as well as that for the combination of the 2 drugs is discussed in this paper. HAI of gemcitabine-oxaliplatin should be evaluated in further clinical trials.
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https://www.hal.inserm.fr/inserm-00475002
Contributor : Pablo Ortega Deballon <>
Submitted on : Wednesday, April 21, 2010 - 10:51:29 AM
Last modification on : Wednesday, June 10, 2020 - 2:06:49 PM

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  • HAL Id : inserm-00475002, version 1
  • PUBMED : 20205288

Citation

Boris Guiu, Julie Vincent, Séverine Guiu, Sylvain Ladoire, Pablo Ortega-Deballon, et al.. Hepatic arterial infusion of gemcitabine-oxaliplatin in a large metastasis from colon cancer.. World Journal of Gastroenterology, Baishideng Publishing Group Co. Limited, 2010, 16 (9), pp.1150-4. ⟨inserm-00475002⟩

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