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Evidence for a positive role of PtdIns5P in T-cell signal transduction pathways.: PtdIns5P and T cell signaling

Abstract : Phosphatidylinositol 5-phosphate (PtdIns5P) is emerging as a potential lipid messenger involved in several cell types, from plants to mammals. Expression of IpgD, a PtdIns(4,5)P(2) 4-phosphatase induces Src kinase and Akt, but not ERK activation and enhances interleukin II promoter activity in T-cells. Expression of a new PtdIns5P interacting domain blocks IpgD-induced T-cell activation and selective signaling molecules downstream of TCR triggering. Altogether, these data suggest that PtdIns5P may play a sensor function in setting the threshold of T-cell activation and contributing to maintain T-cell homeostasis.
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https://www.hal.inserm.fr/inserm-00474713
Contributor : Jacques Nunès <>
Submitted on : Tuesday, April 27, 2010 - 2:46:03 PM
Last modification on : Tuesday, February 18, 2020 - 3:32:02 PM
Long-term archiving on: : Tuesday, September 28, 2010 - 12:08:58 PM

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Geoffrey Guittard, Eva Mortier, Hélène Tronchère, Guylène Firaguay, Audrey Gérard, et al.. Evidence for a positive role of PtdIns5P in T-cell signal transduction pathways.: PtdIns5P and T cell signaling. FEBS Letters, Wiley, 2010, 584 (11), pp.2455-60. ⟨10.1016/j.febslet.2010.04.051⟩. ⟨inserm-00474713⟩

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