Skip to Main content Skip to Navigation
Journal articles

Expression and Function of Kruppel Like-Factors (KLF) in Carcinogenesis.

Abstract : Krüppel-like factor (KLF) family members share a three C2H2 zinc finger DNA binding domain, and are involved in cell proliferation and differentiation control in normal as in pathological situations. Studies over the past several years support a significant role for this family of transcription factors in carcinogenesis. KLFs can both activate and repress genes that participate in cell-cycle regulation. Among them, many up-regulated genes are inhibitors of proliferation, whereas genes that promote cell proliferation are repressed. However, several studies do present KLFs as positive regulator of cell proliferation. KLFs can be deregulated in multiple cancers either by loss of heterozygosity (LOH), somatic mutation or transcriptional silencing by promoter hypermethylation. Accordingly, KLF expression was shown to mediate growth inhibition when ectopically expressed in multiple cancer-derived cell lines through the inhibition of a number of key oncogenic signaling pathways, and to revert the tumorogenic phenotype in vivo. Taken together, these observations suggest that KLFs act as tumor suppressor. However, in some occasion, KLFs could act as tumor promoters, depending on "cellular context". Thus, this review will discuss the roles and the functions of KLF family members in carcinogenesis, with a special focus on cancers from epithelial origin.
Document type :
Journal articles
Complete list of metadatas

https://www.hal.inserm.fr/inserm-00474288
Contributor : Marie Francoise Simon <>
Submitted on : Monday, April 19, 2010 - 3:06:52 PM
Last modification on : Friday, January 10, 2020 - 9:09:10 PM

Links full text

Identifiers

Collections

Citation

Christophe Bureau, Naima Hanoun, Jérôme Torrisani, Jean-Pierre Vinel, Louis Buscail, et al.. Expression and Function of Kruppel Like-Factors (KLF) in Carcinogenesis.. Curr Genomics, 2009, 10 (5), pp.353-60. ⟨10.2174/138920209788921010⟩. ⟨inserm-00474288⟩

Share

Metrics

Record views

129