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Long-term follow-up of autologous stem cell transplantation after intensive chemotherapy in patients with myelodysplastic syndrome or secondary acute myeloid leukemia.

Abstract : We report on the outcomes of 53 patients with myelodysplastic syndromes (MDS) or acute myeloid leukemia secondary to MDS, autografted in first complete remission. Five (9.4%) died from the procedure whereas hematological reconstitution occurred in all the remaining patients. Forty patients (75%) relapsed, with 87.5% of the relapses occurring within 2 years of the autologous transplant. With a median follow-up of 6.2 years, the median actuarial disease-free survival and overall survival were 8 and 17 months after autograft, respectively. Karyotype was the only prognostic factor for disease-free and overall survival. The eight survivors (15%), including two patients with unfavorable or intermediate karyotype, remained in first complete remission 50+ to 119+ months after transplantation and are probably cured.
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https://www.hal.inserm.fr/inserm-00473474
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Submitted on : Tuesday, December 28, 2010 - 1:02:16 PM
Last modification on : Wednesday, September 16, 2020 - 10:43:29 AM
Long-term archiving on: : Tuesday, March 29, 2011 - 2:30:58 AM

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  • HAL Id : inserm-00473474, version 1
  • PUBMED : 16531261

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Sophie Ducastelle, Lionel Adès, Claude Gardin, Hervé Dombret, Thomas Prébet, et al.. Long-term follow-up of autologous stem cell transplantation after intensive chemotherapy in patients with myelodysplastic syndrome or secondary acute myeloid leukemia.. Haematologica, Ferrata Storti Foundation, 2006, 91 (3), pp.373-6. ⟨inserm-00473474⟩

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