Clinical and economic impact of epoetin in adjuvant-chemotherapy for breast cancer.

Philippe Fagnoni 1 Samuel Limat 1, 2 Loïc Chaigneau 3 Emmanuel Guardiola 3 Stéphanie Briaud 1, 3 Bernard Schmitt 4 Yacine Merrouche 5 Xavier Pivot 3, 6 Marie-Christine Woronoff-Lemsi 1
1 Départment de pharmacie
2 Recherches épidémiologiques et cliniques en cancérologie digestive
3 Service d'oncologie Médicale
4 Caisse régionale d'assurance maladie
5 Service d'oncologie
6 HOTE GREFFON - Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098)
Abstract : INTRODUCTION: Anaemia is a common toxicity in cancer patients and epoetins (EPOs) are now an established treatment. The economic profile of EPO treatment was assessed in patients with breast cancer treated by adjuvant-chemotherapy. MATERIALS AND METHODS: Two strategies were compared: without treatment by EPO and with the possible use of treatment by EPO (epoetin alfa) when required. The clinical effectiveness criterion was time adjusted to quality of life and economic data included only direct medical costs. MAIN RESULTS: One hundred ninety-two patients were included. In the group with the strategy containing the possible use of EPO, 45.5% of patients effectively received EPO. A significant difference in the haemoglobin level profile over time was observed which provided a significant overall benefit of 0.0052 (p<10(-4)) quality-adjusted life year (QALY) associated with an extra cost of 1,615 (p<10(-4)). In the base case analysis, the cost per added QALY was estimated as 310,577 with the strategy containing the possible use of EPO. CONCLUSION: This robust result seems to be unacceptable, but the only relevant point of discussion might be the level of acceptable incremental cost-effectiveness ratio (ICER) for a patient.
Type de document :
Article dans une revue
Supportive Care in Cancer, Springer Verlag (Germany), 2006, 14 (10), pp.1030-7. 〈10.1007/s00520-006-0062-5〉
Liste complète des métadonnées
http://www.hal.inserm.fr/inserm-00473467
Contributeur : Philippe Saas <>
Soumis le : jeudi 15 avril 2010 - 11:57:53
Dernière modification le : lundi 9 juillet 2018 - 13:12:02

Lien texte intégral

istex

Identifiants

Collections

UMR645 | UNIV-FCOMTE

Citation

Philippe Fagnoni, Samuel Limat, Loïc Chaigneau, Emmanuel Guardiola, Stéphanie Briaud, et al.. Clinical and economic impact of epoetin in adjuvant-chemotherapy for breast cancer.. Supportive Care in Cancer, Springer Verlag (Germany), 2006, 14 (10), pp.1030-7. 〈10.1007/s00520-006-0062-5〉. 〈inserm-00473467〉

Exporter

BibTeX TEI DC DCterms EndNote

Partager

Métriques

Consultations de la notice

144

Contact

support.ccsd.cnrs.fr
hal.support@ccsd.cnrs.fr
Logo CCSD