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T cell repertoire and Epstein-Barr virus-specific T cell response in chronic active Epstein-Barr virus infection: a case study.

Abstract : In a patient with chronic active Epstein-Barr virus infection associated with vasculitis and fulminant CD4+ T cell lymphoproliferative disorder, we probed the peripheral blood mononuclear cells (PBMC) for the presence of an EBV-specific T cell repertoire and tested the possible relationship between the lymphocytic infiltrate and the EBV-specific T cell response. Our results give credence to the presence of an apparently normal EBV-specific memory T cell response after in vitro reactivation of the patient's PBMC with autologous infected B lymphoblastoid cell lines. In keeping with the characterization of the vasculitis, certain T cell subsets were detected after expansion of skin lesion-infiltrating lymphocytes and were found to be infected with EBV. These particular T cell expansions were neither the effectors nor the targets of the in vitro reactivated EBV-specific T cells, thus excluding a simple relationship between EBV, the skin lesions, and the T cell expansions frequently observed in these patients.
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https://www.hal.inserm.fr/inserm-00473462
Contributor : Philippe Saas <>
Submitted on : Thursday, April 15, 2010 - 11:53:15 AM
Last modification on : Tuesday, October 27, 2020 - 2:35:49 PM

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Géraldine Gallot, Mohamed Hamidou, Béatrice Clémenceau, Joëlle Gaschet, Pierre Tiberghien, et al.. T cell repertoire and Epstein-Barr virus-specific T cell response in chronic active Epstein-Barr virus infection: a case study.. Clinical Immunology, Elsevier, 2006, 119 (1), pp.79-86. ⟨10.1016/j.clim.2005.11.008⟩. ⟨inserm-00473462⟩

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