[Induction chemotherapy in patients with head and neck cancer] - Inserm - Institut national de la santé et de la recherche médicale Access content directly
Journal Articles Bulletin du Cancer Year : 2006

[Induction chemotherapy in patients with head and neck cancer]


Neoadjuvant chemotherapies for patients with advanced head and neck squamous cell carcinoma have been widely studied for twenty years. Despite a high level of activity on the primary tumor, no study has demonstrated a survival benefit suggesting the use of neoadjvant chemotherapy. One can consider that the only benefit of such strategy is for larynx preservation in patients with operable hypopharnx or larynx cancer. Nevertheless, recently the well established preservation strategy based on induction chemotherapy following according to the activity by radiotherapy has been knocked over by a strategy developed by Forastiere et al. using primary concomitant chemoradiotherapy. However, the lack of benefit reported by neoadjuvant chemotherapy has been thwarted by the recent results provided by the EORTC study which assessed the survival benefit of neoadjuvant chemotherapy by docetaxel-cisplatin-fluorouracile. Interestingly, since 2002 the clearly established strategies for patients with advanced head and neck cancer have been challenged and new options are emerging. This paper reviews the standard strategy of the past and the future proposal emerging from recent studies.


Immunology Cancer
Not file

Dates and versions

inserm-00473322 , version 1 (15-04-2010)


  • HAL Id : inserm-00473322 , version 1
  • PUBMED : 16873076


Loïc Chaigneau, Emmanuel Guardiola, Thierry N'Guyen, Armelle Dufresne, Ulrich Stein, et al.. [Induction chemotherapy in patients with head and neck cancer]. Bulletin du Cancer, 2006, 93 (7), pp.677-82. ⟨inserm-00473322⟩


86 View
0 Download



Gmail Facebook Twitter LinkedIn More