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Influenza recombinant vaccine: matrix protein M1 on the platform of the adenovirus dodecahedron.

A. Naskalska 1 Ewa Szolajska 1, 2 Laurence Chaperot 3 Juliette Angel 3 Joël Plumas 4 Jadwiga Chroboczek 2
1 Institute of Biochemistry and Biophysics
2 IBS - UMR 5075 - Institut de biologie structurale
3 INSERM U823 - Institut d'oncologie/développement Albert Bonniot de Grenoble
4 INSERM U823, équipe 9 (Immunobiologie et Immunothérapie des Cancers)
INSERM U823 - Institut d'oncologie/développement Albert Bonniot de Grenoble
Abstract : We propose a novel influenza vaccine composed of the adenovirus dodecahedron (Dd) as delivery platform carrying an internal influenza matrix protein M1. To attach the antigen to the vector we used WW domains interacting with Dd. Successful internalization of the Dd-M1WW complex was observed using biochemical and cell biology techniques. We show here that the complex of Dd with antigen is a potent activator of human myeloid dendritic cells (MDC), and that it is efficiently presented by MDC to M1-specific CD8+ T lymphocytes. These results show that proposed vaccine model is feasible and that adenovirus dodecahedron is a potent delivery platform for foreign antigens to human cells.
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https://www.hal.inserm.fr/inserm-00471451
Contributor : Laurence Chaperot <>
Submitted on : Thursday, April 8, 2010 - 11:53:03 AM
Last modification on : Tuesday, May 11, 2021 - 11:36:03 AM

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INSERM | U823 | CNRS | CEA | IBS | CEA-DRF | IRIG | CEA-GRE | UGA

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A. Naskalska, Ewa Szolajska, Laurence Chaperot, Juliette Angel, Joël Plumas, et al.. Influenza recombinant vaccine: matrix protein M1 on the platform of the adenovirus dodecahedron.. Vaccine, Elsevier, 2009, 27 (52), pp.7385-93. ⟨10.1016/j.vaccine.2009.09.021⟩. ⟨inserm-00471451⟩

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