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Frontal Assessment Battery is a marker of dorsolateral and medial frontal functions: A SPECT study in frontotemporal dementia.

Eric Guedj 1 Gilles Allali 2 Celine Goetz 2 Isabelle Le Ber 2, 3, 4 Magali Volteau 5 Lucette Lacomblez 2, 6, 7 Pierre Vera 8, 9 Anne Hitzel 8, 9 Didier Hannequin 10, 11 Marielle Decousus 12 Catherine Thomas-Antérion 12 Christine Magne 13 Martine Vercelletto 14 Anne-Marie Bernard 15 Mira Didic 16, 17 Jean-Albert Lotterie 18 Michèle Puel 19 Alexis Brice 2, 3 The French Research Network On Ftd/ftd-Mnd Marie-Odile Habert 20, 21 Bruno Dubois 2, 4, 5
Abstract : The objective of this study is to identify the cerebral regions that are assessed by the Frontal Assessment Battery (FAB). Using SPM voxel-based analysis, we looked for correlations between FAB performance and brain SPECT perfusion in 47 patients with the frontal variant of frontotemporal dementia (fv-FTD) recruited by the French FTD research network, a multicentre initiative of French University hospitals with expertise in the field of dementia. A significant correlation was found between FAB performance and perfusion in the medial and dorsolateral frontal cortex bilaterally, independently of age, gender and MMSE. No correlations were observed with orbital frontal or parietal perfusion, in spite of the presence of hypoperfusion in these areas, or with perfusion of any other cortical or subcortical region. These findings confirm that the FAB is an adequate tool for assessing functions related to the dorsolateral and medial frontal cortex, and is thus useful for the evaluation of diseases associated with frontal dysfunction.
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Submitted on : Friday, March 26, 2010 - 11:35:15 AM
Last modification on : Friday, May 20, 2022 - 11:06:23 AM


  • HAL Id : inserm-00467223, version 1
  • PUBMED : 18938766


Eric Guedj, Gilles Allali, Celine Goetz, Isabelle Le Ber, Magali Volteau, et al.. Frontal Assessment Battery is a marker of dorsolateral and medial frontal functions: A SPECT study in frontotemporal dementia.. Journal of the Neurological Sciences, Elsevier, 2008, 273 (1-2), pp.84-7. ⟨inserm-00467223⟩



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