Frontal Assessment Battery is a marker of dorsolateral and medial frontal functions: A SPECT study in frontotemporal dementia. - Archive ouverte HAL Access content directly
Journal Articles Journal of the Neurological Sciences Year : 2008

Frontal Assessment Battery is a marker of dorsolateral and medial frontal functions: A SPECT study in frontotemporal dementia.

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Eric Guedj
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  • PersonId : 861799

Abstract

The objective of this study is to identify the cerebral regions that are assessed by the Frontal Assessment Battery (FAB). Using SPM voxel-based analysis, we looked for correlations between FAB performance and brain SPECT perfusion in 47 patients with the frontal variant of frontotemporal dementia (fv-FTD) recruited by the French FTD research network, a multicentre initiative of French University hospitals with expertise in the field of dementia. A significant correlation was found between FAB performance and perfusion in the medial and dorsolateral frontal cortex bilaterally, independently of age, gender and MMSE. No correlations were observed with orbital frontal or parietal perfusion, in spite of the presence of hypoperfusion in these areas, or with perfusion of any other cortical or subcortical region. These findings confirm that the FAB is an adequate tool for assessing functions related to the dorsolateral and medial frontal cortex, and is thus useful for the evaluation of diseases associated with frontal dysfunction.
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Dates and versions

inserm-00467223 , version 1 (26-03-2010)

Identifiers

  • HAL Id : inserm-00467223 , version 1
  • PUBMED : 18938766

Cite

Eric Guedj, Gilles Allali, Celine Goetz, Isabelle Le Ber, Magali Volteau, et al.. Frontal Assessment Battery is a marker of dorsolateral and medial frontal functions: A SPECT study in frontotemporal dementia.. Journal of the Neurological Sciences, 2008, 273 (1-2), pp.84-7. ⟨inserm-00467223⟩
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