Identification of a C-rich element as a novel cytoplasmic polyadenylation element in Xenopus embryos.

Luc Paillard 1, 2 Dominique Maniey 1, 2 Philippe Lachaume 1, 2 Vincent Legagneux 1, 2 H. Beverley Osborne 1, 2
1 Recombinaions Génétique
2 Faculté de médecine
Abstract : During Xenopus early development, the length of the poly(A) tail of maternal mRNAs is a key element of translational control. Several sequence elements (cytoplasmic polyadenylation elements) localized in 3' untranslated regions have been shown to be responsible for the cytoplasmic polyadenylation of certain maternal mRNAs. Here, we demonstrate that the mRNA encoding the catalytic subunit of phosphatase 2A is polyadenylated after fertilization of Xenopus eggs. This polyadenylation is mediated by the additive effects of two cis elements, one being similar to already described cytoplasmic polyadenylation elements and the other consisting of a polycytosine motif. Finally, a candidate specificity factor for polycytosine-mediated cytoplasmic polyadenylation has been purified and identified as the Xenopus homologue of human alpha-CP2.
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Article dans une revue
Mechanisms of Development, Elsevier, 2000, 93 (1-2), pp.117-25
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http://www.hal.inserm.fr/inserm-00467031
Contributeur : Vincent Legagneux <>
Soumis le : jeudi 25 mars 2010 - 16:34:58
Dernière modification le : mercredi 16 mai 2018 - 11:23:31

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  • HAL Id : inserm-00467031, version 1
  • PUBMED : 10781945

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Luc Paillard, Dominique Maniey, Philippe Lachaume, Vincent Legagneux, H. Beverley Osborne. Identification of a C-rich element as a novel cytoplasmic polyadenylation element in Xenopus embryos.. Mechanisms of Development, Elsevier, 2000, 93 (1-2), pp.117-25. 〈inserm-00467031〉

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