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Introduction to chromosome dynamics in mitosis.

Abstract : To ensure that the genetic information, replicated in the S-phase of the cell cycle, is correctly distributed between daughter cells at mitosis, chromatin duplication and chromosome segregation are highly regulated events. Since the early 1980's, our knowledge of the mechanisms governing these two events has greatly increased due to the use of genetic and biochemical approaches. We present here, first, an overview of the replication process, highlighting molecular aspects involved in coupling replication with chromatin dynamics in mitosis. The second part will present the current understanding of chromosome condensation and segregation during mitosis in higher eukaryotes. Finally, we will underline the links that exist between replication and mitosis.
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Contributor : Vincent Legagneux Connect in order to contact the contributor
Submitted on : Thursday, March 25, 2010 - 3:06:54 PM
Last modification on : Wednesday, March 30, 2022 - 2:34:33 PM

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Erwan Watrin, Vincent Legagneux. Introduction to chromosome dynamics in mitosis.. Biology of the Cell, Wiley, 2003, 95 (8), pp.507-13. ⟨10.1016/j.biolcel.2003.08.003⟩. ⟨inserm-00466990⟩



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