Skip to Main content Skip to Navigation
Journal articles

Multiple roles of Condensins: a complex story.

Abstract : Condensins are pentameric complexes that were initially described as being involved in the dynamics of chromosomes during mitosis. It has been recently established that two related complexes (Condensin I and Condensin II) contribute to this process. An increasing sum of studies, using different approaches in various organisms, leads to the paradigm that Condensins are required for the correct segregation of replicated chromosomes by cooperating somehow with Topoisomerase II in sister chromatid resolution. Depending on species and/or experimental studies, these complexes also contribute to some aspects of the assembly and compaction of mitotic chromosomes. Recent studies provided evidences that Condensins and related complexes also function in non-mitotic processes such as replication and transcription. Biochemical studies have highlighted mechanistic aspects of Condensin function and initiated a fine functional dissection of core and regulatory subunits. However, the exact contribution of each subunit remains largely elusive as well as the functional interplay between Condensin I and Condensin II.
Document type :
Journal articles
Complete list of metadatas

https://www.hal.inserm.fr/inserm-00466987
Contributor : Vincent Legagneux <>
Submitted on : Thursday, March 25, 2010 - 3:04:19 PM
Last modification on : Monday, November 9, 2020 - 11:08:03 AM

Links full text

Identifiers

Citation

Vincent Legagneux, Fabien Cubizolles, Erwan Watrin. Multiple roles of Condensins: a complex story.. Biology of the Cell, Wiley, 2004, 96 (3), pp.201-13. ⟨10.1016/j.biolcel.2004.01.003⟩. ⟨inserm-00466987⟩

Share

Metrics

Record views

176