Chromosome wide analysis of CUGBP1 binding sites identifies the tetraspanin CD9 mRNA as a target for CUGBP1-mediated down-regulation.

Olivier Le Tonquèze; Bernhard Gschloessl; Allen Namanda-Vanderbeken; Vincent Legagneux; Luc Paillard; Yann Audic

doi:10.1016/j.bbrc.2010.03.020

Journal articles

Chromosome wide analysis of CUGBP1 binding sites identifies the tetraspanin CD9 mRNA as a target for CUGBP1-mediated down-regulation.

Olivier Le Tonquèze ^{1, 2} Bernhard Gschloessl ^{1, 2} Allen Namanda-Vanderbeken ^{1, 2} Vincent Legagneux ^{1, 2} Luc Paillard ^{1, 2} Yann Audic ^{1, 2, *}

* Corresponding author

1 IGDR - Institut de Génétique et Développement de Rennes

2 UEB - Université européenne de Bretagne - European University of Brittany

Abstract : CUGBP1 is an RNA-binding protein controlling alternative splicing, mRNA translation and stability. In this work we used a motif scoring approach to identify putative CUGBP1 binding sites for genes located on the human chromosome 12. This allowed us to identify the gene CD9 as a presumptive target for CUGBP1-mediated regulation. In a number of cancers, the tetraspanin CD9 is down-regulated, an event correlated with a bad prognostic. Using a combination of biochemical approaches and CUGBP1 knockdown, we showed that CUGBP1 directly controls CD9 expression.

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Journal articles

Domain :

Life Sciences [q-bio] / Biochemistry, Molecular Biology

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https://www.hal.inserm.fr/inserm-00466153
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Submitted on : Monday, March 22, 2010 - 6:07:55 PM
Last modification on : Thursday, October 8, 2020 - 3:06:42 AM

Chromosome wide analysis of CUGBP1 binding sites identifies the tetraspanin CD9 mRNA as a target for CUGBP1-mediated down-regulation.

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Chromosome wide analysis of CUGBP1 binding sites identifies the tetraspanin CD9 mRNA as a target for CUGBP1-mediated down-regulation.

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