Chromosome wide analysis of CUGBP1 binding sites identifies the tetraspanin CD9 mRNA as a target for CUGBP1-mediated down-regulation. - Archive ouverte HAL Access content directly
Journal Articles Biochemical and Biophysical Research Communications Year : 2010

Chromosome wide analysis of CUGBP1 binding sites identifies the tetraspanin CD9 mRNA as a target for CUGBP1-mediated down-regulation.

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Abstract

CUGBP1 is an RNA-binding protein controlling alternative splicing, mRNA translation and stability. In this work we used a motif scoring approach to identify putative CUGBP1 binding sites for genes located on the human chromosome 12. This allowed us to identify the gene CD9 as a presumptive target for CUGBP1-mediated regulation. In a number of cancers, the tetraspanin CD9 is down-regulated, an event correlated with a bad prognostic. Using a combination of biochemical approaches and CUGBP1 knockdown, we showed that CUGBP1 directly controls CD9 expression.
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Dates and versions

inserm-00466153 , version 1 (22-03-2010)

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Olivier Le Tonquèze, Bernhard Gschloessl, Allen Namanda-Vanderbeken, Vincent Legagneux, Luc Paillard, et al.. Chromosome wide analysis of CUGBP1 binding sites identifies the tetraspanin CD9 mRNA as a target for CUGBP1-mediated down-regulation.. Biochemical and Biophysical Research Communications, 2010, 394 (4), pp.884-9. ⟨10.1016/j.bbrc.2010.03.020⟩. ⟨inserm-00466153⟩
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