Chromosome wide analysis of CUGBP1 binding sites identifies the tetraspanin CD9 mRNA as a target for CUGBP1-mediated down-regulation.

Olivier Le Tonquèze 1, 2 Bernhard Gschloessl 1, 2 Allen Namanda-Vanderbeken 1, 2 Vincent Legagneux 1, 2 Luc Paillard 1, 2 Yann Audic 1, 2, *
* Corresponding author
1 IGDR - Institut de Génétique et Développement de Rennes
2 UEB - Université européenne de Bretagne - European University of Brittany
Abstract : CUGBP1 is an RNA-binding protein controlling alternative splicing, mRNA translation and stability. In this work we used a motif scoring approach to identify putative CUGBP1 binding sites for genes located on the human chromosome 12. This allowed us to identify the gene CD9 as a presumptive target for CUGBP1-mediated regulation. In a number of cancers, the tetraspanin CD9 is down-regulated, an event correlated with a bad prognostic. Using a combination of biochemical approaches and CUGBP1 knockdown, we showed that CUGBP1 directly controls CD9 expression.
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Journal articles
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https://www.hal.inserm.fr/inserm-00466153
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Submitted on : Monday, March 22, 2010 - 6:07:55 PM
Last modification on : Tuesday, October 22, 2019 - 11:42:05 AM

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CNRS | UNIV-RENNES1 | IGDR | BIOSIT | UR1-UFR-SVE | UNIV-RENNES

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Olivier Le Tonquèze, Bernhard Gschloessl, Allen Namanda-Vanderbeken, Vincent Legagneux, Luc Paillard, et al.. Chromosome wide analysis of CUGBP1 binding sites identifies the tetraspanin CD9 mRNA as a target for CUGBP1-mediated down-regulation.. Biochemical and Biophysical Research Communications, Elsevier, 2010, 394 (4), pp.884-9. ⟨10.1016/j.bbrc.2010.03.020⟩. ⟨inserm-00466153⟩

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