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Delineation of 15q13.3 microdeletions.

Alice Masurel-Paulet 1, 2 Joris Andrieux 3 Patrick Callier 4 Jean-Marie Cuisset 5 Cédric Le Caignec 6 Muriel Holder-Espinasse 7 Christel Thauvin-Robinet 1, 2 Bérénice Doray 8 Elizabeth Flori 9 Marie-Pierre Alex-Cordier 10 Mylène Beri 11 Odile Boute 7 Bruno Delobel 12 Anne Dieux 7 Louis Vallée 5 Sylvie Jaillard 13 Sylvie Odent 14 Bertrand Isidor 6 Claire Beneteau 15 Jaqueline Vigneron 15 Frédéric Bilan 16 Brigitte Gilbert-Dussardier 16 Christele Dubourg 17 Audrey Labalme 18 C. Bidon 19 Agnès Gautier 20 Philippe Pernes 21 Jean-Michel Pinoit 22 Frédéric Huet 1 Francine Mugneret 1 Bernard Aral 15 Philippe Jonveaux 23 Damien Sanlaville 18 Laurence Faivre 1, 2, * 
Abstract : The increasing use of array-comparative genomic hybridization (array-CGH) to identify copy number variations (CNVs) in patients with developmental delay (DD), mental retardation and/or dysmorphic features has allowed the recent recognition of numerous genomic imbalances, including the 15q13.3 microdeletion. Patients with this microdeletion generally present with relatively consistent breakpoints at BP4 and BP5, which include the CHRNA7 gene. About 100 index cases have been reported since the first publication in 2008. This large number of patients ascertained through highly variable samples has been necessary to describe the full phenotypic spectrum of this microdeletion, ranging from mental retardation with dysmorphic features, epilepsy, neuropsychiatric disturbances with or without cognitive impairment to complete absence of anomalies. Here, we describe a collaborative study reporting a new cohort of 12 index patients and 13 relatives carrying a heterozygous BP4-BP5 microdeletion out of a series of 4625 patients screened by array-CGH for DD. We confirm the clinical expressivity of the disease as well as the incomplete penetrance in seven families. We showed through a review of the literature that males are more likely to be symptomatic. Sequence analysis of CHRNA7 yielded no data to support the unmasking of recessive variants as a cause of phenotypic variability. We also report the first patient carrying a 15q13.3 homozygous microdeletion inherited from both parents. He had severe epileptic encephalopathy with retinopathy, autistic features and choreoathetosis. Besides the classical approximately 1.5 Mb BP4-BP5 microdeletion, we also describe three index patients and two relatives with a smaller 500 kb microdeletion, including the CHRNA7 gene.
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Submitted on : Monday, March 22, 2010 - 5:48:35 PM
Last modification on : Tuesday, April 26, 2022 - 1:54:08 PM

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Alice Masurel-Paulet, Joris Andrieux, Patrick Callier, Jean-Marie Cuisset, Cédric Le Caignec, et al.. Delineation of 15q13.3 microdeletions.. Clinical Genetics, Wiley, 2010, 78 (2), pp.149-61. ⟨10.1111/j.1399-0004.2010.01374.x⟩. ⟨inserm-00466147⟩



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