Y. Keynan and E. Rubinstein, The changing face of Klebsiella pneumoniae infections in the community, International Journal of Antimicrobial Agents, vol.30, issue.5, pp.385-394, 2007.
DOI : 10.1016/j.ijantimicag.2007.06.019

C. Fang, S. Lai, W. Yi, P. Hsueh, and K. Liu, Klebsiella pneumoniae Genotype K1: An Emerging Pathogen That Causes Septic Ocular or Central Nervous System Complications from Pyogenic Liver Abscess, Clinical Infectious Diseases, vol.45, issue.3, pp.284-93, 2007.
DOI : 10.1086/519262

S. Su, L. Siu, L. Ma, K. Yeh, and C. Fung, Community-Acquired Liver Abscess Caused by Serotype K1 Klebsiella pneumoniae with CTX-M-15-Type Extended-Spectrum ??-Lactamase, Antimicrobial Agents and Chemotherapy, vol.52, issue.2, pp.804-809, 2008.
DOI : 10.1128/AAC.01269-07

G. Jacoby, D. Mills, and N. Chow, Role of ??-Lactamases and Porins in Resistance to Ertapenem and Other ??-Lactams in Klebsiella pneumoniae, Antimicrobial Agents and Chemotherapy, vol.48, issue.8, pp.3203-3209, 2004.
DOI : 10.1128/AAC.48.8.3203-3206.2004

K. Bush, G. Jacoby, and A. Medeiros, A functional classification scheme for beta-lactamases and its correlation with molecular structure, Antimicrobial Agents and Chemotherapy, vol.39, issue.6, pp.1211-1244, 1995.
DOI : 10.1128/AAC.39.6.1211

A. Davin-regli, J. Bolla, C. James, J. Lavigne, and J. Chevalier, Membrane Permeability and Regulation of Drug “Influx and Efflux” in Enterobacterial Pathogens, Current Drug Targets, vol.9, issue.9, pp.750-759, 2008.
DOI : 10.2174/138945008785747824

P. Gruteke, W. Goessens, J. Gils, P. Peerbooms, and N. Lemmens-den-toom, Patterns of Resistance Associated with Integrons, the Extended-Spectrum ??-Lactamase SHV-5 Gene, and a Multidrug Efflux Pump of Klebsiella pneumoniae Causing a Nosocomial Outbreak, Journal of Clinical Microbiology, vol.41, issue.3, pp.1161-1167, 2003.
DOI : 10.1128/JCM.41.3.1161-1166.2003

S. Haeggman, S. Lofdahl, A. Paauw, J. Verhoef, and S. Brisse, Diversity and Evolution of the Class A Chromosomal Beta-Lactamase Gene in Klebsiella pneumoniae, Antimicrobial Agents and Chemotherapy, vol.48, issue.7, pp.2400-2408, 2004.
DOI : 10.1128/AAC.48.7.2400-2408.2004

K. Poole, Efflux-mediated antimicrobial resistance, Journal of Antimicrobial Chemotherapy, vol.56, issue.1, pp.20-51, 2005.
DOI : 10.1093/jac/dki171

X. Li and H. Nikaido, Efflux-Mediated Drug Resistance in Bacteria, Drugs, vol.182, issue.8, pp.159-204, 2004.
DOI : 10.2165/00003495-200464020-00004

J. Pagès, C. James, and M. Winterhalter, The porin and the permeating antibiotic: a selective diffusion barrier in Gram-negative bacteria, Nature Reviews Microbiology, vol.390, issue.12, pp.893-903, 2008.
DOI : 10.1016/S0969-2126(99)80055-0

U. Hasdemir, C. J. Nordmann, P. Pagès, and J. , Detection and Prevalence of Active Drug Efflux Mechanism in Various Multidrug-Resistant Klebsiella pneumoniae Strains from Turkey, Journal of Clinical Microbiology, vol.42, issue.6, pp.2701-2707, 2004.
DOI : 10.1128/JCM.42.6.2701-2706.2004

J. Chevalier, J. Pagès, A. Eyraud, and M. Malléa, Membrane Permeability Modifications Are Involved in Antibiotic Resistance in Klebsiella pneumoniae, Biochemical and Biophysical Research Communications, vol.274, issue.2, pp.496-99, 2000.
DOI : 10.1006/bbrc.2000.3159

O. Lomovskaya and K. Bostian, Practical applications and feasibility of efflux pump inhibitors in the clinic???A vision for applied use, Biochemical Pharmacology, vol.71, issue.7, pp.910-928, 2006.
DOI : 10.1016/j.bcp.2005.12.008

A. Mahamoud, J. Chevalier, S. Alibert-franco, W. Kern, and J. Pagès, Antibiotic efflux pumps in Gram-negative bacteria: the inhibitor response strategy, Journal of Antimicrobial Chemotherapy, vol.59, issue.6, pp.1223-1252, 2007.
DOI : 10.1093/jac/dkl493

URL : https://hal.archives-ouvertes.fr/hal-01425047

E. Pradel and J. Pagès, The AcrAB-TolC Efflux Pump Contributes to Multidrug Resistance in the Nosocomial Pathogen Enterobacter aerogenes, Antimicrobial Agents and Chemotherapy, vol.46, issue.8, pp.2640-2683, 2002.
DOI : 10.1128/AAC.46.8.2640-2643.2002

F. Perez, A. Endimiani, K. Hujer, and R. Bonomo, The continuing challenge of ESBLs, Current Opinion in Pharmacology, vol.7, issue.5, pp.459-69, 2007.
DOI : 10.1016/j.coph.2007.08.003

M. Malléa, C. J. Bornet, C. Eyraud, A. Davin-regli, and A. , Porin alteration and active efflux: two in vivo drug resistance strategies used by Enterobacter aerogenes, Microbiology, vol.144, issue.11, pp.3003-3012, 1998.
DOI : 10.1099/00221287-144-11-3003

L. Piddock, Multidrug-resistance efflux pumps ??? not just for resistance, Nature Reviews Microbiology, vol.95, issue.8, pp.629-665, 2006.
DOI : 10.1038/nrmicro1464

C. Su, H. Nikaido, and E. Yu, Ligand-transporter interaction in the AcrB multidrug efflux pump determined by fluorescence polarization assay, FEBS Letters, vol.129, issue.25, pp.4972-4978, 2005.
DOI : 10.1016/j.febslet.2007.09.035

R. Chollet, C. J. Bryskier, A. Pagès, and J. , The AcrAB-TolC Pump Is Involved in Macrolide Resistance but Not in Telithromycin Efflux in Enterobacter aerogenes and Escherichia coli, Antimicrobial Agents and Chemotherapy, vol.48, issue.9, pp.3621-3625, 2004.
DOI : 10.1128/AAC.48.9.3621-3624.2004

E. Yu, J. Aires, G. Mcdermott, and H. Nikaido, A Periplasmic Drug-Binding Site of the AcrB Multidrug Efflux Pump: a Crystallographic and Site-Directed Mutagenesis Study, Journal of Bacteriology, vol.187, issue.19, pp.6804-6819, 2005.
DOI : 10.1128/JB.187.19.6804-6815.2005

M. Seeger, V. Ballmoos, C. Eicher, T. Brandstatter, L. Verrey et al., Engineered disulfide bonds support the functional rotation mechanism of multidrug efflux pump AcrB, Nature Structural & Molecular Biology, vol.292, issue.2, pp.199-205, 2008.
DOI : 10.1038/nsmb.1379

C. Elkins and L. Mullis, Substrate Competition Studies Using Whole-Cell Accumulation Assays with the Major Tripartite Multidrug Efflux Pumps of Escherichia coli, Antimicrobial Agents and Chemotherapy, vol.51, issue.3, pp.923-932, 2007.
DOI : 10.1128/AAC.01048-06

V. Dastidar, W. Mao, O. Lomovskaya, and H. Zgurskaya, Drug-Induced Conformational Changes in Multidrug Efflux Transporter AcrB from Haemophilus influenzae, Journal of Bacteriology, vol.189, issue.15, pp.5550-5558, 2007.
DOI : 10.1128/JB.00471-07

N. Mesaros, P. Nordmann, P. Plesiat, M. Roussel-delvallez, and J. Van-eldere, Pseudomonas aeruginosa: resistance and therapeutic options at the turn of the new millennium, Clinical Microbiology and Infection, vol.13, issue.6, pp.560-78, 2007.
DOI : 10.1111/j.1469-0691.2007.01681.x

URL : https://hal.archives-ouvertes.fr/hal-00510521

J. Pagès and L. Amaral, Mechanisms of drug efflux and strategies to combat them: Challenging the efflux pump of Gram-negative bacteria, Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, vol.1794, issue.5, 2009.
DOI : 10.1016/j.bbapap.2008.12.011

V. Ricci, P. Tzakas, A. Buckley, and L. Piddock, Ciprofloxacin-Resistant Salmonella enterica Serovar Typhimurium Strains Are Difficult To Select in the Absence of AcrB and TolC, Antimicrobial Agents and Chemotherapy, vol.50, issue.1, pp.38-42, 2006.
DOI : 10.1128/AAC.50.1.38-42.2006

M. Yan, O. Sahin, J. Lin, and Q. Zhang, Role of the CmeABC efflux pump in the emergence of fluoroquinolone-resistant Campylobacter under selection pressure, Journal of Antimicrobial Chemotherapy, vol.58, issue.6, pp.1154-1163, 2006.
DOI : 10.1093/jac/dkl412

C. Elkins and H. Nikaido, 3D structure of AcrB: the archetypal multidrug efflux transporter of Escherichia coli likely captures substrates from periplasm, Drug Resistance Updates, vol.6, issue.1, pp.9-13, 2003.
DOI : 10.1016/S1368-7646(03)00004-9

O. Lomovskaya and M. Totrov, Vacuuming the Periplasm, Journal of Bacteriology, vol.187, issue.6, pp.1879-83, 2005.
DOI : 10.1128/JB.187.6.1879-1883.2005

C. Bornet, R. Chollet, M. Malléa, C. J. Davin-regli, and A. , Imipenem and expression of multidrug efflux pump in Enterobacter aerogenes, Biochemical and Biophysical Research Communications, vol.301, issue.4, pp.985-90, 2003.
DOI : 10.1016/S0006-291X(03)00074-3

A. Gori, F. Espinasse, A. Deplano, C. Nonhoff, and M. Nicolas, Comparison of pulsed-field gel electrophoresis and randomly amplified DNA polymorphism analysis for typing extended-spectrum-ß-lactamase-producing Klebsiella pneumoniae, J Clin Microbiol, vol.34, pp.2448-53, 1996.

L. Armand-lefèvre, V. Leflon-guibout, J. Bredin, F. Barguellil, and A. Amor, Imipenem Resistance in Salmonella enterica Serovar Wien Related to Porin Loss and CMY-4 ??-Lactamase Production, Antimicrobial Agents and Chemotherapy, vol.47, issue.3, pp.1165-1173, 2003.
DOI : 10.1128/AAC.47.3.1165-1168.2003

V. Simonet, M. Malléa, D. Fourel, J. Bolla, and J. Pagès, Crucial domains are conserved in Enterobacteriaceae porins, FEMS Microbiology Letters, vol.136, issue.1, pp.91-98, 1996.
DOI : 10.1111/j.1574-6968.1996.tb08030.x

J. Chevalier, C. Mulfinger, E. Garnotel, P. Nicolas, A. Davin-regli et al., Identification and Evolution of Drug Efflux Pump in Clinical Enterobacter aerogenes Strains Isolated in 1995 and 2003, PLoS ONE, vol.42, issue.2, p.3203, 1995.
DOI : 10.1371/journal.pone.0003203.t005

V. Cattoir, L. Poirel, V. Rotimi, C. Soussy, and P. Nordmann, Multiplex PCR for detection of plasmid-mediated quinolone resistance qnr genes in ESBL-producing enterobacterial isolates, Journal of Antimicrobial Chemotherapy, vol.60, issue.2, pp.394-401, 2007.
DOI : 10.1093/jac/dkm204

V. Leflon-guibout, C. Jurand, S. Bonacorsi, F. Espinasse, and M. Guelfi, Emergence and Spread of Three Clonally Related Virulent Isolates of CTX-M-15-Producing Escherichia coli with Variable Resistance to Aminoglycosides and Tetracycline in a French Geriatric Hospital, Antimicrobial Agents and Chemotherapy, vol.48, issue.10, pp.3736-3778, 2004.
DOI : 10.1128/AAC.48.10.3736-3742.2004