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Human intestinal microbiota gene risk factors for antibiotic-associated diarrhea: perspectives for prevention. Risk factors for antibiotic-associated diarrhea.: Diarrhea risk prediction from microbiota genes

Abstract : Antibiotic-associated diarrhea (AAD) is associated with altered intestinal microflora and other symptoms that may lead to possibly death. In critically ill patients, diarrhea increases rates of morbimortality. Assessing diarrhea risks is thus important for clinicians. For this reason, we conducted a hypothesis-generating study focused on AAD to provide insight into methods of prevention. We evaluated the hypothesis of predisposing factors within the resident intestinal microbiota in a cohort of outpatients receiving antibiotherapy. Among the pool of tested variables, only those related to bacterial 16S rRNA genes were found to be relevant. Complex statistical analyses provided further information: amid the bacteria 16S rRNA genes, eight were determined to be essential for diarrhea predisposition and characterized from the most important to the least. Using these markers, AAD risk could be estimated with an error of 2%. This molecular analysis offers new perspectives for clinical applications at the level of prevention.
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https://www.hal.inserm.fr/inserm-00462416
Contributor : Marie France de la Cochetière <>
Submitted on : Tuesday, March 9, 2010 - 4:02:34 PM
Last modification on : Friday, October 23, 2020 - 4:44:09 PM
Long-term archiving on: : Friday, June 18, 2010 - 10:35:05 PM

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Marie France de la Cochetière, Emmanuel Montassier, Jean-Benoît Hardouin, Thomas Carton, Françoise Le Vacon, et al.. Human intestinal microbiota gene risk factors for antibiotic-associated diarrhea: perspectives for prevention. Risk factors for antibiotic-associated diarrhea.: Diarrhea risk prediction from microbiota genes. Microbial Ecology, Springer Verlag, 2010, 59 (4), pp.830-7. ⟨10.1007/s00248-010-9637-2⟩. ⟨inserm-00462416⟩

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