EUELC project: a multi-centre, multipurpose study to investigate early stage NSCLC, and to establish a biobank for ongoing collaboration.
John K. Field
(1, 2)
,
Triantafillos Liloglou
(1)
,
Asaf Niaz
(1)
,
J. Bryan
(1)
,
J. R. Gosney
(3)
,
T. Giles
(4)
,
Christian Brambilla
(5)
,
Elisabeth Brambilla
(5)
,
Aurélien Vesin
(5)
,
Jean-François Timsit
(5)
,
Pierre Hainaut
(6)
,
Yves Martinet
(7, 8)
,
J. M. Vignaud
(7, 8)
,
Frederik B. Thunnissen
(9, 10)
,
Clemens Prinsen
(9)
,
Peter J. Snijders
(10)
,
E. F. Smit
(11)
,
Gabriella Sozzi
(12)
,
Luca Roz
(12)
,
Angela Risch
(13)
,
Heinrich D. Becker
(14)
,
J. Stuart Elborn
(15)
,
N. D. Magee
(15)
,
Luis M. Montuenga
(16)
,
Maria J. Pajares
(16)
,
M. D. Lozano
(16)
,
Ken J. O'Byrne
(17)
,
D. J. Harrison
(18)
,
Jacek Niklinski
(19)
,
Adrian Cassidy
(2)
,
Non Renseigné
1
Canc Res Ctr
2 Canc Res Ctr, Roy Castle Lung Canc Res Programme
3 Sch Canc Studies
4 Dept Cytopathol
5 INSERM U823 - Institut d'oncologie/développement Albert Bonniot de Grenoble
6 Int Agcy Res Canc
7 CRB Nancy - Centre de Ressources Biologiques - [Nancy]
8 NGERE - Nutrition-Génétique et Exposition aux Risques Environnementaux
9 Dept Pathol
10 Med Ctr, Dept Pathol
11 Med Ctr, Dept Pulmonol
12 Dept Expt Oncol & Labs
13 DKFZ - German Cancer Research Center - Deutsches Krebsforschungszentrum [Heidelberg]
14 Thoraxklin Heidelberg Univ
15 Ctr Infect & Immun, Resp Med Res Grp
16 Ctr Appl Med Res CIMA
17 St James Hosp
18 Queens Med Res Inst, Div Pathol
19 Dept Thorac Surg
2 Canc Res Ctr, Roy Castle Lung Canc Res Programme
3 Sch Canc Studies
4 Dept Cytopathol
5 INSERM U823 - Institut d'oncologie/développement Albert Bonniot de Grenoble
6 Int Agcy Res Canc
7 CRB Nancy - Centre de Ressources Biologiques - [Nancy]
8 NGERE - Nutrition-Génétique et Exposition aux Risques Environnementaux
9 Dept Pathol
10 Med Ctr, Dept Pathol
11 Med Ctr, Dept Pulmonol
12 Dept Expt Oncol & Labs
13 DKFZ - German Cancer Research Center - Deutsches Krebsforschungszentrum [Heidelberg]
14 Thoraxklin Heidelberg Univ
15 Ctr Infect & Immun, Resp Med Res Grp
16 Ctr Appl Med Res CIMA
17 St James Hosp
18 Queens Med Res Inst, Div Pathol
19 Dept Thorac Surg
Christian Brambilla
- Fonction : Auteur
- PersonId : 932361
Jean-François Timsit
- Fonction : Auteur
- PersonId : 758651
- ORCID : 0000-0002-6063-7383
- IdRef : 077116313
Non Renseigné
- Fonction : Auteur
Résumé
The European Early Lung Cancer (EUELC) project aims to determine if specific genetic alterations occurring in lung carcinogenesis are detectable in the respiratory epithelium. In order to pursue this objective, nonsmall cell lung cancer (NSCLC) patients with a very high risk of developing progressive lung cancer were recruited from 12 centres in eight European countries: France, Germany, southern Ireland, Italy, the Netherlands, Poland, Spain and the UK. In addition, NSCLC patients were followed up every 6 months for 36 months. A European Bronchial Tissue Bank was set up at the University of Liverpool (Liverpool, UK) to optimise the use of biological specimens. The molecular-pathological investigations were subdivided into specific work packages that were delivered by EUELC Partners. The work packages encompassed mutational analysis, genetic instability, methylation profiling, expression profiling utilising immunohistochemistry and chip-based technologies, as well as in-depth analysis of FHIT and RARbeta genes, the telomerase catalytic subunit hTERT and genotyping of susceptibility genes in specific pathways. The EUELC project engendered a tremendous collaborative effort, and it enabled the EUELC Partners to establish protocols for assessing molecular biomarkers in early lung cancer with the view to using such biomarkers for early diagnosis and as intermediate end-points in future chemopreventive programmes.