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EUELC project: a multi-centre, multipurpose study to investigate early stage NSCLC, and to establish a biobank for ongoing collaboration.

John K. Field 1, 2 Triantafillos Liloglou 1 Asaf Niaz 1 J. Bryan 1 J. R. Gosney 3 T. Giles 4 Christian Brambilla 5 Elisabeth Brambilla 6 Aurélien Vesin 7 Jean-François Timsit 8 Pierre Hainaut 9 Yves Martinet 10, 11 J. M. Vignaud 10, 11 Frederik B. Thunnissen 12, 13 Clemens Prinsen 12 Peter J. Snijders 13 E. F. Smit 14 Gabriella Sozzi 15 Luca Roz 15 Angela Risch 16 Heinrich D. Becker 17 J. Stuart Elborn 18 N. D. Magee 18 Luis M. Montuenga 19 Maria J. Pajares 19 M. D. Lozano 19 Ken J. O'Byrne 20 D. J. Harrison 21 Jacek Niklinski 22 Adrian Cassidy 2 Non Renseigné 
Abstract : The European Early Lung Cancer (EUELC) project aims to determine if specific genetic alterations occurring in lung carcinogenesis are detectable in the respiratory epithelium. In order to pursue this objective, nonsmall cell lung cancer (NSCLC) patients with a very high risk of developing progressive lung cancer were recruited from 12 centres in eight European countries: France, Germany, southern Ireland, Italy, the Netherlands, Poland, Spain and the UK. In addition, NSCLC patients were followed up every 6 months for 36 months. A European Bronchial Tissue Bank was set up at the University of Liverpool (Liverpool, UK) to optimise the use of biological specimens. The molecular-pathological investigations were subdivided into specific work packages that were delivered by EUELC Partners. The work packages encompassed mutational analysis, genetic instability, methylation profiling, expression profiling utilising immunohistochemistry and chip-based technologies, as well as in-depth analysis of FHIT and RARbeta genes, the telomerase catalytic subunit hTERT and genotyping of susceptibility genes in specific pathways. The EUELC project engendered a tremendous collaborative effort, and it enabled the EUELC Partners to establish protocols for assessing molecular biomarkers in early lung cancer with the view to using such biomarkers for early diagnosis and as intermediate end-points in future chemopreventive programmes.
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Submitted on : Thursday, February 4, 2010 - 10:04:47 AM
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John K. Field, Triantafillos Liloglou, Asaf Niaz, J. Bryan, J. R. Gosney, et al.. EUELC project: a multi-centre, multipurpose study to investigate early stage NSCLC, and to establish a biobank for ongoing collaboration.. European Respiratory Journal, European Respiratory Society, 2009, 34 (6), pp.1477-86. ⟨10.1183/09031936.00077809⟩. ⟨inserm-00453198⟩



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