[Non-fatal disseminated mucormycosis in a solid organ transplant]

Abstract : BACKGROUND: Mucormycosis is a rare fungal infection occurring most frequently in immunocompromised patients. The pathogens are filamentous fungi, order of Mucorales. Disseminated mucormycosis is a severe, life treating disease. Early diagnosis is a major determinant for prognosis, however, it remains difficult. The management consists in an early antifungal therapy using lipid formulation of amphotericin B associated with an extensive surgical debridement. Despite this therapeutic of choice, the mortality of disseminated mucormycosis remains high. OBSERVATION: We report the case of disseminated mucormycosis in a 25 years old woman 9 months after a pulmonary transplantation. The clinical presentation included pulmonary and thyroid localization and the pathogen was Absidia corymbifera. The patient survived thanks to a large surgical debridement, and an early antifungal bitherapy by lipid formulation of amphotericin B and posaconazole. CONCLUSION: The re-emergence and the high mortality of mucormycosis in solid organ transplant receiver show the necessity to find new therapeutic approaches. Posaconazole associated with liposomal amphotericin B could be an interesting option to treat disseminated mucormycosis and improve their outcome.
Type de document :
Article dans une revue
Revue des Maladies Respiratoires, Elsevier Masson, 2009, 26 (9), pp.998-1002
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http://www.hal.inserm.fr/inserm-00453180
Contributeur : Aurélien Vesin <>
Soumis le : jeudi 4 février 2010 - 09:17:31
Dernière modification le : mercredi 10 janvier 2018 - 10:12:03

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  • HAL Id : inserm-00453180, version 1
  • PUBMED : 19953048

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U823 | UGA

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Clémence Minet, Agnès Bonadona, Alexis Tabah, Alexandre Karkas, L. Mescam, et al.. [Non-fatal disseminated mucormycosis in a solid organ transplant]. Revue des Maladies Respiratoires, Elsevier Masson, 2009, 26 (9), pp.998-1002. 〈inserm-00453180〉

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