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Therapy-induced tumor immunosurveillance involves IFN-producing killer dendritic cells.

Abstract : A unique class of IFN-producing killer dendritic cells (IKDC) resembling natural killer cells has been defined that can recognize and lyse tumor cells through a tumor necrosis factor-related apoptosis-inducing ligand-dependent mechanism. IKDC may mediate the host-dependent antitumor activity of Gleevec/STI571 and other therapeutics that can inhibit the c-kit tyrosine kinase. IKDC represent an important new component of the innate immune system responding to cancer.
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https://www.hal.inserm.fr/inserm-00451703
Contributor : Grégoire Mignot <>
Submitted on : Friday, January 29, 2010 - 5:37:46 PM
Last modification on : Wednesday, September 16, 2020 - 5:04:55 PM

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Evelyn Ullrich, Mathieu Bonmort, Grégoire Mignot, Nathalie Chaput, Julien Taieb, et al.. Therapy-induced tumor immunosurveillance involves IFN-producing killer dendritic cells.. Cancer Research, American Association for Cancer Research, 2007, 67 (3), pp.851-3. ⟨10.1158/0008-5472.CAN-06-3766⟩. ⟨inserm-00451703⟩

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