D. Parkin, Global cancer statistics in the year 2000, The Lancet Oncology, vol.2, issue.9, pp.533-543, 2001.
DOI : 10.1016/S1470-2045(01)00486-7

. Ménard, Reptin silencing blocks liver cancer progression 15

J. Blanc, C. Lalanne, C. Plomion, J. Schmitter, K. Bathany et al., Proteomic analysis of differentially expressed proteins in hepatocellular carcinoma developed in patients with chronic viral hepatitis???C, PROTEOMICS, vol.36, issue.14, pp.3778-3789, 2005.
DOI : 10.1002/pmic.200401194

M. Wood, S. Mcmahon, and M. Cole, An ATPase/Helicase Complex Is an Essential Cofactor for Oncogenic Transformation by c-Myc, Molecular Cell, vol.5, issue.2, pp.321-330, 2000.
DOI : 10.1016/S1097-2765(00)80427-X

A. Bauer, S. Chauvet, O. Huber, F. Usseglio, U. Rothbacher et al., Pontin52 and Reptin52 function as antagonistic regulators of beta-catenin signalling activity, The EMBO Journal, vol.19, issue.22, pp.6121-6130, 2000.
DOI : 10.1093/emboj/19.22.6121

X. Shen, G. Mizuguchi, A. Hamiche, and C. Wu, A chromatin remodelling complex involved in transcription and DNA processing, Nature, vol.406, issue.6795, pp.541-544, 2000.
DOI : 10.1038/35020123

U. Salzer, M. Kubicek, and R. Prohaska, Isolation, molecular characterization, and tissue-specific expression of ECP-51 and ECP-54 (TIP49), two homologous, interacting erythroid cytosolic proteins, Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, vol.1446, issue.3, pp.365-370, 1999.
DOI : 10.1016/S0167-4781(99)00104-9

M. Ammelburg, T. Frickey, and A. Lupas, Classification of AAA+ proteins, Journal of Structural Biology, vol.156, issue.1, pp.2-11, 2006.
DOI : 10.1016/j.jsb.2006.05.002

. Ménard, Reptin silencing blocks liver cancer progression 16

L. Iyer, D. Leipe, E. Koonin, and L. Aravind, Evolutionary history and higher order classification of AAA+ ATPases, Journal of Structural Biology, vol.146, issue.1-2, pp.11-31, 2004.
DOI : 10.1016/j.jsb.2003.10.010

Z. Jonsson, S. Dhar, G. Narlikar, R. Auty, N. Wagle et al., Rvb1p and Rvb2p Are Essential Components of a Chromatin Remodeling Complex That Regulates Transcription of over 5% of Yeast Genes, Journal of Biological Chemistry, vol.276, issue.19, pp.16279-16288, 2001.
DOI : 10.1074/jbc.M011523200

C. Etard, D. Gradl, M. Kunz, M. Eilers, and D. Wedlich, Pontin and Reptin regulate cell proliferation in early Xenopus embryos in collaboration with c-Myc and Miz-1, Mechanisms of Development, vol.122, issue.4, pp.545-556, 2005.
DOI : 10.1016/j.mod.2004.11.010

P. Bellosta, T. Hulf, B. Diop, S. Usseglio, F. Pradel et al., Myc interacts genetically with Tip48/Reptin and Tip49/Pontin to control growth and proliferation during Drosophila development, Proceedings of the National Academy of Sciences, vol.102, issue.33, pp.11799-11804, 2005.
DOI : 10.1073/pnas.0408945102
URL : https://hal.archives-ouvertes.fr/hal-00118754

J. Jin, Y. Cai, T. Yao, A. Gottschalk, L. Florens et al., A Mammalian Chromatin Remodeling Complex with Similarities to the Yeast INO80 Complex, Journal of Biological Chemistry, vol.280, issue.50, pp.41207-41212, 2005.
DOI : 10.1074/jbc.M509128200

J. Kim, B. Kim, L. Cai, H. Choi, K. Ohgi et al., Transcriptional regulation of a metastasis suppressor gene by Tip60 and ??-catenin complexes, Nature, vol.223, issue.7035, pp.921-926, 2005.
DOI : 10.1074/jbc.M100846200

K. Schmeichel and M. Bissell, Modeling tissue-specific signaling and organ function in three dimensions, Journal of Cell Science, vol.116, issue.12, pp.2377-2388, 2003.
DOI : 10.1242/jcs.00503

. Ménard, Reptin silencing blocks liver cancer progression 17

W. Mueller-klieser, Tumor biology and experimental therapeutics, Critical Reviews in Oncology/Hematology, vol.36, issue.2-3, pp.123-139, 2000.
DOI : 10.1016/S1040-8428(00)00082-2

V. Haurie, L. Ménard, A. Nicou, C. Touriol, P. Metzler et al., Adenosine triphosphatase pontin is overexpressed in hepatocellular carcinoma and coregulated with reptin through a new posttranslational mechanism, Hepatology, vol.18, issue.6, pp.1871-1883, 2009.
DOI : 10.1002/hep.23215
URL : https://hal.archives-ouvertes.fr/inserm-00408518

V. Neaud, G. Duplantier, J. Mazzocco, C. Kisiel, W. Rosenbaum et al., Thrombin Up-regulates Tissue Factor Pathway Inhibitor-2 Synthesis through a Cyclooxygenase-2-dependent, Epidermal Growth Factor Receptor-independent Mechanism, Journal of Biological Chemistry, vol.279, issue.7, pp.5200-5206, 2004.
DOI : 10.1074/jbc.M306679200

P. Adams, Remodeling of chromatin structure in senescent cells and its potential impact on tumor suppression and aging, Gene, vol.397, issue.1-2, pp.84-93, 2007.
DOI : 10.1016/j.gene.2007.04.020

K. Livak and T. Schmittgen, Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2???????CT Method, Methods, vol.25, issue.4, pp.402-408, 2001.
DOI : 10.1006/meth.2001.1262

M. Wiznerowicz and D. Trono, Conditional Suppression of Cellular Genes: Lentivirus Vector-Mediated Drug-Inducible RNA Interference, Journal of Virology, vol.77, issue.16, pp.8957-8961, 2003.
DOI : 10.1128/JVI.77.16.8957-8951.2003

U. Deuschle, W. Meyer, and H. Thiesen, Tetracycline-reversible silencing of eukaryotic promoters., Molecular and Cellular Biology, vol.15, issue.4, pp.1907-1914, 1995.
DOI : 10.1128/MCB.15.4.1907

R. Urrutia, KRAB-containing zinc-finger repressor proteins, Genome Biology, vol.4, issue.10, p.231, 2003.
DOI : 10.1186/gb-2003-4-10-231

. Ménard, Reptin silencing blocks liver cancer progression 18

M. Prochazka, H. Gaskins, L. Shultz, and E. Leiter, The nonobese diabetic scid mouse: model for spontaneous thymomagenesis associated with immunodeficiency., Proceedings of the National Academy of Sciences, vol.89, issue.8, pp.3290-3294, 1992.
DOI : 10.1073/pnas.89.8.3290

S. Matsukura, P. Jones, D. Takai, S. Kappel, B. Spankuch et al., Establishment of conditional vectors for hairpin siRNA knockdowns, Nucleic Acids Research, vol.31, issue.15, 2003.
DOI : 10.1093/nar/gng077

A. Ventura, A. Meissner, C. Dillon, M. Mcmanus, P. Sharp et al., Conditional inhibition of cancer cell proliferation by tetracycline-responsive, H1 promoterdriven silencing of PLK1 Crelox-regulated conditional RNA interference from transgenes, Oncogene Proc Natl Acad Sci U S A, vol.24101, issue.33, pp.2973-298010380, 2004.

H. Cheng, R. Snoek, F. Ghaidi, M. Cox, and P. Rennie, Short Hairpin RNA Knockdown of the Androgen Receptor Attenuates Ligand-Independent Activation and Delays Tumor Progression, Cancer Research, vol.66, issue.21
DOI : 10.1158/0008-5472.CAN-06-0028

N. Ke, D. Zhou, J. Chatterton, G. Liu, J. Chionis et al., A new inducible RNAi xenograft model for assessing the staged tumor response to mTOR silencing, Experimental Cell Research, vol.312, issue.15, pp.2726-2734, 2006.
DOI : 10.1016/j.yexcr.2006.05.001

L. Li, X. Lin, M. Staver, A. Shoemaker, D. Semizarov et al., Evaluating Hypoxia-Inducible Factor-1?? as a Cancer Therapeutic Target via Inducible RNA Interference In vivo, Cancer Research, vol.65, issue.16, pp.7249-7258, 2005.
DOI : 10.1158/0008-5472.CAN-04-4426

R. Taulli, C. Scuoppo, F. Bersani, P. Accornero, P. Forni et al., Validation of Met as a Therapeutic Target in Alveolar and Embryonal Rhabdomyosarcoma, Cancer Research, vol.66, issue.9, pp.4742-4749, 2006.
DOI : 10.1158/0008-5472.CAN-05-4292

G. Hannon and J. Rossi, Unlocking the potential of the human genome with RNA interference, Nature, vol.2, issue.7006, pp.371-378, 2004.
DOI : 10.1074/jbc.M307089200

. Ménard, Reptin silencing blocks liver cancer progression 19

H. Chan, M. Narita, S. Lowe, and D. Livingston, The p400 E1A-associated protein is a novel component of the p53 -> p21 senescence pathway, Genes & Development, vol.19, issue.2, pp.196-201, 2005.
DOI : 10.1101/gad.1280205

S. Kubicka, C. Trautwein, M. Niehof, and M. Manns, Target gene modulation in hepatocellular carcinomas by decreased DNA-binding of p53 mutations, Hepatology, vol.25, issue.4, pp.867-873, 1997.
DOI : 10.1002/hep.510250414

W. Rottbauer, A. Saurin, H. Lickert, X. Shen, C. Burns et al., Reptin and Pontin Antagonistically Regulate Heart Growth in Zebrafish Embryos, Cell, vol.111, issue.5, pp.661-672, 2002.
DOI : 10.1016/S0092-8674(02)01112-1
URL : https://hal.archives-ouvertes.fr/hal-00311059