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Journal Articles European Journal of Radiology Year : 2009

CT characteristics of resolving ground-glass opacities in a lung cancer screening programme.

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Abstract

PURPOSE: This study aimed at evaluating the computed tomography (CT) characteristics of resolving localized ground-glass opacities (GGOs) in a screening programme for lung cancer. MATERIAL AND METHODS: 280 patients at high-risk for lung cancer (221 men, 59 women; mean age, 58.6 years), divided into four groups (lung cancer history (n=83), head and neck cancer history (n=63), symptomatic (n=88) and asymptomatic (n=46) cigarette smokers), were included in a prospective trial with annual low-dose CT for lung cancer screening. We retrospectively reviewed all localized GGOs, analyzed the CT characteristics on initial CT scans and changes during follow-up (median 29.1 months). Variables associated with resolution of GGOs were tested using chi-square or Mann-Whitney tests. RESULTS: A total of 75 GGOs were detected in 37 patients; 54.7% were present at baseline and 45.3% appeared on annual CT. During follow-up, 56.2% persisted and 43.8% disappeared. The resolving localized GGOs were significantly more often lobular GGOs (p=0.006), polygonal in shape (p=0.02), mixed (p=0.003) and larger (p<0.0001) than non-resolving localized GGOs. CONCLUSION: Localized GGOs are frequent and many disappeared on follow-up. CT characteristics of resolving GGOs show significant differences compared to persistent ones. This study emphasizes the importance of short-term CT follow-up in subjects with localized GGOs.
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inserm-00449329 , version 1 (21-01-2010)

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Laure Felix, Géraldine Serra-Tosio, Sylvie Lantuejoul, Jean-François Timsit, Denis Moro-Sibilot, et al.. CT characteristics of resolving ground-glass opacities in a lung cancer screening programme.. European Journal of Radiology, 2009, epub ahead of print. ⟨10.1016/j.ejrad.2009.09.008⟩. ⟨inserm-00449329⟩

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