Skip to Main content Skip to Navigation
Journal articles

CT characteristics of resolving ground-glass opacities in a lung cancer screening programme.

Abstract : PURPOSE: This study aimed at evaluating the computed tomography (CT) characteristics of resolving localized ground-glass opacities (GGOs) in a screening programme for lung cancer. MATERIAL AND METHODS: 280 patients at high-risk for lung cancer (221 men, 59 women; mean age, 58.6 years), divided into four groups (lung cancer history (n=83), head and neck cancer history (n=63), symptomatic (n=88) and asymptomatic (n=46) cigarette smokers), were included in a prospective trial with annual low-dose CT for lung cancer screening. We retrospectively reviewed all localized GGOs, analyzed the CT characteristics on initial CT scans and changes during follow-up (median 29.1 months). Variables associated with resolution of GGOs were tested using chi-square or Mann-Whitney tests. RESULTS: A total of 75 GGOs were detected in 37 patients; 54.7% were present at baseline and 45.3% appeared on annual CT. During follow-up, 56.2% persisted and 43.8% disappeared. The resolving localized GGOs were significantly more often lobular GGOs (p=0.006), polygonal in shape (p=0.02), mixed (p=0.003) and larger (p<0.0001) than non-resolving localized GGOs. CONCLUSION: Localized GGOs are frequent and many disappeared on follow-up. CT characteristics of resolving GGOs show significant differences compared to persistent ones. This study emphasizes the importance of short-term CT follow-up in subjects with localized GGOs.
Document type :
Journal articles
Complete list of metadatas

https://www.hal.inserm.fr/inserm-00449329
Contributor : Aurélien Vesin <>
Submitted on : Thursday, January 21, 2010 - 11:38:03 AM
Last modification on : Wednesday, January 10, 2018 - 10:12:03 AM

Identifiers

Collections

U823 | UGA

Citation

Laure Felix, Géraldine Serra-Tosio, Sylvie Lantuejoul, Jean-François Timsit, Denis Moro-Sibilot, et al.. CT characteristics of resolving ground-glass opacities in a lung cancer screening programme.. European Journal of Radiology, Elsevier, 2009, epub ahead of print. ⟨10.1016/j.ejrad.2009.09.008⟩. ⟨inserm-00449329⟩

Share

Metrics

Record views

216