Skip to Main content Skip to Navigation
Journal articles

Heat-shock factor 1 controls genome-wide acetylation in heat-shocked cells.

Abstract : A major regulatory function has been evidenced here for HSF1, the key transcription factor of the heat-shock response, in a large-scale remodeling of the cell epigenome. Indeed, upon heat shock, HSF1, in addition to its well-known transactivating activities, mediates a genome-wide and massive histone deacetylation. Investigating the underlying mechanisms, we show that HSF1 specifically associates with and uses HDAC1 and HDAC2 to trigger this heat-shock-dependent histone deacetylation. This work therefore identifies HSF1 as a master regulator of global chromatin acetylation and reveals a cross-talk between HSF1 and histone deacetylases in the general control of genome organization in response to heat shock.
Document type :
Journal articles
Complete list of metadatas

Cited literature [39 references]  Display  Hide  Download
Contributor : Catherine Souchier <>
Submitted on : Tuesday, January 5, 2010 - 4:55:35 PM
Last modification on : Wednesday, January 20, 2021 - 3:24:01 PM
Long-term archiving on: : Thursday, June 17, 2010 - 10:20:26 PM


Publisher files allowed on an open archive




Sabrina Fritah, Edwige Col, Cyril Boyault, Jérôme Govin, Karin Sadoul, et al.. Heat-shock factor 1 controls genome-wide acetylation in heat-shocked cells.. Molecular Biology of the Cell, American Society for Cell Biology, 2009, 20 (23), pp.4976-84. ⟨10.1091/mbc.E09-04-0295⟩. ⟨inserm-00444109⟩



Record views


Files downloads