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Heat-shock factor 1 controls genome-wide acetylation in heat-shocked cells.

Abstract : A major regulatory function has been evidenced here for HSF1, the key transcription factor of the heat-shock response, in a large-scale remodeling of the cell epigenome. Indeed, upon heat shock, HSF1, in addition to its well-known transactivating activities, mediates a genome-wide and massive histone deacetylation. Investigating the underlying mechanisms, we show that HSF1 specifically associates with and uses HDAC1 and HDAC2 to trigger this heat-shock-dependent histone deacetylation. This work therefore identifies HSF1 as a master regulator of global chromatin acetylation and reveals a cross-talk between HSF1 and histone deacetylases in the general control of genome organization in response to heat shock.
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https://www.hal.inserm.fr/inserm-00444109
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Submitted on : Tuesday, January 5, 2010 - 4:55:35 PM
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Sabrina Fritah, Edwige Col, Cyril Boyault, Jérôme Govin, Karin Sadoul, et al.. Heat-shock factor 1 controls genome-wide acetylation in heat-shocked cells.. Molecular Biology of the Cell, American Society for Cell Biology, 2009, 20 (23), pp.4976-84. ⟨10.1091/mbc.E09-04-0295⟩. ⟨inserm-00444109⟩

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