Heat-shock factor 1 controls genome-wide acetylation in heat-shocked cells. - Archive ouverte HAL Access content directly
Journal Articles Molecular Biology of the Cell Year : 2009

Heat-shock factor 1 controls genome-wide acetylation in heat-shocked cells.

(1) , (2) , (1) , (1) , (1) , (3) , (4) , (5) , (1) , (6)
1
2
3
4
5
6

Abstract

A major regulatory function has been evidenced here for HSF1, the key transcription factor of the heat-shock response, in a large-scale remodeling of the cell epigenome. Indeed, upon heat shock, HSF1, in addition to its well-known transactivating activities, mediates a genome-wide and massive histone deacetylation. Investigating the underlying mechanisms, we show that HSF1 specifically associates with and uses HDAC1 and HDAC2 to trigger this heat-shock-dependent histone deacetylation. This work therefore identifies HSF1 as a master regulator of global chromatin acetylation and reveals a cross-talk between HSF1 and histone deacetylases in the general control of genome organization in response to heat shock.
Fichier principal
Vignette du fichier
fritah-2009.pdf (1.31 Mo) Télécharger le fichier
Origin : Publisher files allowed on an open archive
Loading...

Dates and versions

inserm-00444109 , version 1 (05-01-2010)

Identifiers

Cite

Sabrina Fritah, Edwige Col, Cyril Boyault, Jérôme Govin, Karin Sadoul, et al.. Heat-shock factor 1 controls genome-wide acetylation in heat-shocked cells.. Molecular Biology of the Cell, 2009, 20 (23), pp.4976-84. ⟨10.1091/mbc.E09-04-0295⟩. ⟨inserm-00444109⟩
209 View
414 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More