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[The future of antibody fragments, made of a single immunoglobulin domain.]

Patrick Chames 1, * Daniel Baty 1
* Corresponding author
Abstract : Monoclonal antibodies are now established as key therapeutics for a range of diseases including cancer and auto-immunity. However, despite important improvements, these molecules still face several serious limitations including production costs and tumor penetration. A new class of antibody fragments, made of a single immunoglobulin domain, is emerging as an exciting alternative. This review describes the outstanding properties and the first achievements of these domain antibodies. double dagger.
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https://www.hal.inserm.fr/inserm-00443810
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Submitted on : Tuesday, July 6, 2010 - 10:40:19 AM
Last modification on : Thursday, March 5, 2020 - 6:59:40 PM
Long-term archiving on: : Wednesday, November 30, 2016 - 10:18:12 AM

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  • HAL Id : inserm-00443810, version 1
  • PUBMED : 20035698

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Patrick Chames, Daniel Baty. [The future of antibody fragments, made of a single immunoglobulin domain.]. médecine/sciences, EDP Sciences, 2009, 25 (12), pp.1159-62. ⟨inserm-00443810⟩

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