[The future of antibody fragments, made of a single immunoglobulin domain.] - Archive ouverte HAL Access content directly
Journal Articles médecine/sciences Year : 2009

[The future of antibody fragments, made of a single immunoglobulin domain.]

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Patrick Chames
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Daniel Baty
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Abstract

Monoclonal antibodies are now established as key therapeutics for a range of diseases including cancer and auto-immunity. However, despite important improvements, these molecules still face several serious limitations including production costs and tumor penetration. A new class of antibody fragments, made of a single immunoglobulin domain, is emerging as an exciting alternative. This review describes the outstanding properties and the first achievements of these domain antibodies. double dagger.
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Dates and versions

inserm-00443810 , version 1 (06-07-2010)

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  • HAL Id : inserm-00443810 , version 1
  • PUBMED : 20035698

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Patrick Chames, Daniel Baty. [The future of antibody fragments, made of a single immunoglobulin domain.]. médecine/sciences, 2009, 25 (12), pp.1159-62. ⟨inserm-00443810⟩

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