Skip to Main content Skip to Navigation
Journal articles

Cellular models for the screening and development of anti-hepatitis C virus agents.

Abstract : Investigations on the biology of hepatitis C virus (HCV) have been hampered by the lack of small animal models. Efforts have therefore been directed to designing practical and robust cellular models of human origin able to support HCV replication and production in a reproducible, reliable and consistent manner. Many different models based on different forms of virions and hepatoma or other cell types have been described including virus-like particles, pseudotyped particles, subgenomic and full length replicons, virion productive replicons, immortalised hepatocytes, fetal and adult primary human hepatocytes. This review focuses on these different cellular models, their advantages and disadvantages at the biological and experimental levels, and their respective use for evaluating the effect of antiviral molecules on different steps of HCV biology including virus entry, replication, particles generation and excretion, as well as on the modulation by the virus of the host cell response to infection.
Complete list of metadata

Cited literature [306 references]  Display  Hide  Download
Contributor : Patrick Maurel Connect in order to contact the contributor
Submitted on : Wednesday, December 16, 2009 - 10:21:46 AM
Last modification on : Tuesday, March 15, 2022 - 9:31:52 AM
Long-term archiving on: : Thursday, October 18, 2012 - 10:56:54 AM


Files produced by the author(s)




Claire Gondeau, Lydiane Pichard-Garcia, Patrick Maurel. Cellular models for the screening and development of anti-hepatitis C virus agents.. Pharmacology & Therapeutics / Pharmacology and Therapeutics, 2009, 124 (1), pp.1-22. ⟨10.1016/j.pharmthera.2009.05.010⟩. ⟨inserm-00441330⟩



Record views


Files downloads