Bone morphogenic protein 6: a member of a novel class of prognostic factors expressed by normal and malignant plasma cells inhibiting proliferation and angiogenesis. - Archive ouverte HAL Access content directly
Journal Articles Oncogene Year : 2009

Bone morphogenic protein 6: a member of a novel class of prognostic factors expressed by normal and malignant plasma cells inhibiting proliferation and angiogenesis.

(1) , (1) , (2) , (1, 3) , (4) , (5) , (1) , (2) , (6) , (6) , (1) , (1) , (1) , (2) , (7) , (2) , (2) , (1, 4) , (2) , (1, 4)
1
2
3
4
5
6
7
Jérôme Moreaux
John de Vos

Abstract

Pathogenesis of multiple myeloma is associated with an aberrant expression of pro-proliferative, pro-angiogenic and bone-metabolism-modifying factors by malignant plasma cells. Given the frequently long time span from diagnosis of early-stage plasma cell dyscrasias to overt myeloma and the mostly low proliferation rate of malignant plasma cells, we hypothesize these to similarly express a novel class of inhibitory factors of potential prognostic relevance. Bone morphogenic proteins (BMPs) represent possible candidates as they inhibit proliferation, stimulate bone formation and have an effect on the survival of cancer patients. We assessed the expression of BMPs and their receptors by Affymetrix DNA microarrays (n=779) including CD138-purified primary myeloma cell samples (n=635) of previously untreated patients. BMP6 is the only BMP expressed by malignant and normal plasma cells. Its expression is significantly lower in proliferating myeloma cells, myeloma cell lines or plasmablasts. BMP6 significantly inhibits the proliferation of myeloma cell lines, survival of primary myeloma cells and in vitro angiogenesis. A high BMP6 expression in primary myeloma cell samples delineates significantly superior overall survival for patients undergoing high-dose chemotherapy independent of conventional prognostic factors (International Staging System (ISS) stage, beta(2) microglobulin).
Fichier principal
Vignette du fichier
BMP6_in_Myeloma_Suppl_Material_Oncogene_Resubmission.pdf (70.44 Ko) Télécharger le fichier
Vignette du fichier
BMP6_in_Myeloma_Figures_Oncogene_Resubmission.pdf (731.06 Ko) Télécharger le fichier
Vignette du fichier
BMP6_in_Myeloma_Figures_Oncogene_Resubmission.ppt (1.47 Mo) Télécharger le fichier
Vignette du fichier
BMP6_in_Myeloma_Manuscript_Oncogene_Resubmission.pdf (123.13 Ko) Télécharger le fichier
Vignette du fichier
inserm-00437705_edited.pdf (706.09 Ko) Télécharger le fichier
Origin : Files produced by the author(s)
Origin : Files produced by the author(s)
Format : Other
Origin : Files produced by the author(s)
Origin : Files produced by the author(s)
Loading...

Dates and versions

inserm-00437705 , version 1 (26-02-2010)

Identifiers

Cite

Anja Seckinger, Tobias Meissner, Jérôme Moreaux, Hartmut Goldschmidt, Gwenny M. Fuhler, et al.. Bone morphogenic protein 6: a member of a novel class of prognostic factors expressed by normal and malignant plasma cells inhibiting proliferation and angiogenesis.. Oncogene, 2009, 28 (44), pp.3866-79. ⟨10.1038/onc.2009.257⟩. ⟨inserm-00437705⟩
309 View
1701 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More