CD9 expression can be used to predict childhood TEL/AML1-positive acute lymphoblastic leukemia: proposal for an accelerated diagnostic flowchart.

Virginie Gandemer 1, 2 Marc Aubry 3 Mikael Roussel 4 Anne-Gaelle Rio 1 Marie De Tayrac 1 Audrey Vallée 1 Jean Mosser 1, 3, 5 Béatrice Ly-Sunnaram 4 Marie-Dominique Galibert 1, 5
1 IGDR - Institut de Génétique et Développement de Rennes
2 Hématogoie pédiatrique
3 Plate-forme transcriptome
4 HITC - Service d'Hématologie, Immunologie et de Thérapie Cellulaire
5 Service de Génétique Moléculaire et Génomique
Abstract : CD9 has been shown to be differentially expressed in childhood TEL/AML1-positive acute lymphoblastic leukemia (ALL). We confirmed this finding in large Affymetrix data sets and in 80 new cases at both RNA and protein levels. Moreover, we showed that mean fluorescence intensity of CD9 by flow cytometry can distinguish TEL/AML1-positive ALL from other BCP-ALL. Using ROC analysis, the most efficient model for predicting TEL/AML1-positive ALL combined CD9 (mean fluorescence intensity 40%). Finally, we propose a faster procedure for optimizing the diagnosis of childhood BCP-ALL subgroups.
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Article dans une revue
Leukemia Research, Elsevier, 2010, 34 (4), pp.430-7. 〈10.1016/j.leukres.2009.09.033〉
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http://www.hal.inserm.fr/inserm-00435146
Contributeur : Hervé De Villemeur <>
Soumis le : lundi 23 novembre 2009 - 16:26:55
Dernière modification le : mercredi 16 mai 2018 - 11:23:35

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IGDR | BIOSIT | UR1-UFR-SVE | UNIV-RENNES

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Virginie Gandemer, Marc Aubry, Mikael Roussel, Anne-Gaelle Rio, Marie De Tayrac, et al.. CD9 expression can be used to predict childhood TEL/AML1-positive acute lymphoblastic leukemia: proposal for an accelerated diagnostic flowchart.. Leukemia Research, Elsevier, 2010, 34 (4), pp.430-7. 〈10.1016/j.leukres.2009.09.033〉. 〈inserm-00435146〉

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