CD9 expression can be used to predict childhood TEL/AML1-positive acute lymphoblastic leukemia: proposal for an accelerated diagnostic flowchart. - Inserm - Institut national de la santé et de la recherche médicale Accéder directement au contenu
Article Dans Une Revue Leukemia Research Année : 2010

CD9 expression can be used to predict childhood TEL/AML1-positive acute lymphoblastic leukemia: proposal for an accelerated diagnostic flowchart.

Résumé

CD9 has been shown to be differentially expressed in childhood TEL/AML1-positive acute lymphoblastic leukemia (ALL). We confirmed this finding in large Affymetrix data sets and in 80 new cases at both RNA and protein levels. Moreover, we showed that mean fluorescence intensity of CD9 by flow cytometry can distinguish TEL/AML1-positive ALL from other BCP-ALL. Using ROC analysis, the most efficient model for predicting TEL/AML1-positive ALL combined CD9 (mean fluorescence intensity 40%). Finally, we propose a faster procedure for optimizing the diagnosis of childhood BCP-ALL subgroups.

Domaines

Cancer Hématologie

Dates et versions

inserm-00435146 , version 1 (23-11-2009)

Identifiants

Citer

Virginie Gandemer, Marc Aubry, Mikael Roussel, Anne-Gaelle Rio, Marie de Tayrac, et al.. CD9 expression can be used to predict childhood TEL/AML1-positive acute lymphoblastic leukemia: proposal for an accelerated diagnostic flowchart.. Leukemia Research, 2010, 34 (4), pp.430-7. ⟨10.1016/j.leukres.2009.09.033⟩. ⟨inserm-00435146⟩
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