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Journal articles
CD9 expression can be used to predict childhood TEL/AML1-positive acute lymphoblastic leukemia: proposal for an accelerated diagnostic flowchart.
Virginie Gandemer
1, 2
Marc Aubry
3
Mikael Roussel
4
Anne-Gaelle Rio
1
Marie de Tayrac
1
Audrey Vallée
1
Jean Mosser
1, 3, 5
Béatrice Ly-Sunnaram
4
Marie-Dominique Galibert
1, 5
Virginie Gandemer 1, 2
Author
Marc Aubry 3
Author IdHAL : marc-aubry ORCID : https://orcid.org/0000-0002-6954-8141
Mikael Roussel 4
Author IdHAL : mikael-roussel ResearcherId : http://www.researcherid.com/rid/C-3080-2017 ORCID : https://orcid.org/0000-0002-9741-0668
Anne-Gaelle Rio 1
Author
Marie de Tayrac 1
Author
Audrey Vallée 1
Author
Jean Mosser 1, 3, 5
Author
Béatrice Ly-Sunnaram 4
Author
Marie-Dominique Galibert 1, 5
Author
1
IGDR - Institut de Génétique et Développement de Rennes (Faculté de Médecine - CS 34317 2 Av du Professeur Léon Bernard 35043 RENNES CEDEX - France)
- UR1 - Université de Rennes 1 (2 rue du Thabor - CS 46510 - 35065 Rennes cedex - France)
- UNIV-RENNES - Université de Rennes (France)
- IFR140 (France)
- CNRS - Centre National de la Recherche Scientifique : UMR6061 (France)
2
Hématogoie pédiatrique (Rennes - France)
4
HITC - Service d'Hématologie, Immunologie et de Thérapie Cellulaire (2 rue Henri Le Guilloux 35033 RENNES cedex 9 - France)
- UR1 - Université de Rennes 1 (2 rue du Thabor - CS 46510 - 35065 Rennes cedex - France)
- UNIV-RENNES - Université de Rennes (France)
- Hôpital Pontchaillou (France)
- CHU Pontchaillou [Rennes] (2 Rue Henri le Guilloux, 35000 Rennes - France)
5
Service de Génétique Moléculaire et Génomique (2 rue Henri Le Guilloux 35033 Rennes cedex 9 - France)
- Hôpital Pontchaillou (France)
- CHU Pontchaillou [Rennes] (2 Rue Henri le Guilloux, 35000 Rennes - France)
Abstract : CD9 has been shown to be differentially expressed in childhood TEL/AML1-positive acute lymphoblastic leukemia (ALL). We confirmed this finding in large Affymetrix data sets and in 80 new cases at both RNA and protein levels. Moreover, we showed that mean fluorescence intensity of CD9 by flow cytometry can distinguish TEL/AML1-positive ALL from other BCP-ALL. Using ROC analysis, the most efficient model for predicting TEL/AML1-positive ALL combined CD9 (mean fluorescence intensity 40%). Finally, we propose a faster procedure for optimizing the diagnosis of childhood BCP-ALL subgroups.
Document type :
Journal articles
Complete list of metadatas
https://www.hal.inserm.fr/inserm-00435146
Contributor : Hervé de Villemeur <>
Submitted on : Monday, November 23, 2009 - 4:26:55 PM
Last modification on : Saturday, February 15, 2020 - 7:16:05 PM
Contributor : Hervé de Villemeur <>
Submitted on : Monday, November 23, 2009 - 4:26:55 PM
Last modification on : Saturday, February 15, 2020 - 7:16:05 PM
Identifiers
- HAL Id : inserm-00435146, version 1
- DOI : 10.1016/j.leukres.2009.09.033
- PUBMED : 19896186
Collections
CNRS | IGDR | UNIV-RENNES1 | BIOSIT | UR1-UFR-SVE | UNIV-RENNES
Citation
Virginie Gandemer, Marc Aubry, Mikael Roussel, Anne-Gaelle Rio, Marie de Tayrac, et al.. CD9 expression can be used to predict childhood TEL/AML1-positive acute lymphoblastic leukemia: proposal for an accelerated diagnostic flowchart.. Leukemia Research, Elsevier, 2010, 34 (4), pp.430-7. ⟨10.1016/j.leukres.2009.09.033⟩. ⟨inserm-00435146⟩
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