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[Brain-gut axis dysfunction]

Bruno Bonaz 1, * Jean-Marc Sabaté 2, 3
* Corresponding author
1 INSERM U836, équipe 8, Stress et interactions neurodigestives
GIN - Grenoble Institut des Neurosciences, Clinique Universitaire d'Hépato-Gastroentérologie
Abstract : There is a bidirectional relation between the central nervous system and the digestive tract, i.e., the brain-gut axis. Numerous data argue for a dysfunction of the brain-gut axis in the pathophysiology of irritable bowel syndrome (IBS). Visceral hypersensitivity is a marker of IBS as well as of an abnormality of the brain-gut axis. This visceral hypersensitivity is peripheral and/or central in origin and may be the consequence of digestive inflammation or an anomaly of the nociceptive message treatment at the spinal and/or supraspinal level. Stress is involved in the genesis and maintenance of IBS. Disturbances of the autonomic nervous system are observed in IBS as a consequence of brain-gut axis dysfunction. The contribution of the neurosciences, in particular brain imaging techniques, has contributed to the better understanding of IBS physiopathology. The better knowledge of brain-gut axis dysfunction has therapeutic implications, either through drugs and/or cognitive and behavioral therapies.
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https://www.hal.inserm.fr/inserm-00432343
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Submitted on : Monday, November 16, 2009 - 11:17:02 AM
Last modification on : Friday, January 10, 2020 - 3:42:17 PM
Long-term archiving on: : Saturday, November 26, 2016 - 2:16:30 PM

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Bruno Bonaz, Jean-Marc Sabaté. [Brain-gut axis dysfunction]. Gastroentérologie Clinique et Biologique / Research and Clinics in Hepatology and Gastroenterology, Elsevier Masson, 2009, 33 Suppl 1, pp.S48-58. ⟨10.1016/S0399-8320(09)71525-8⟩. ⟨inserm-00432343⟩

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