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Hyperglycemia, type 2 diabetes, and depressive symptoms: the British Whitehall II study.

Abstract : OBJECTIVE: To examine the recent suggestion that impaired fasting glucose may protect against depression, whereas a diagnosis of diabetes might then result in depression. RESEARCH DESIGN AND METHODS: Cross-sectional analysis of 4,228 adults (mean age 60.7 years, 73.0% men) who underwent oral glucose tolerance testing and completed the Center for Epidemiologic Studies Depression scale (CES-D). RESULTS: After adjustment for demographic factors, health behaviors, and clinical measurements (BMI, waist circumference, lipid profile, and blood pressure), there was a U-shaped association between fasting glucose and depression (P(curve) = 0.001), with elevated CES-D at low and very high glucose levels. This finding was replicable with 2-h postload glucose (P = 0.11) and A1C (P = 0.007). CONCLUSIONS: The U-shaped association between blood glucose and CES-D, with the lowest depression risk seen among those in the normoglycemic range of A1C, did not support the hypothesized protective effect of hyperglycemia.
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Submitted on : Monday, October 26, 2009 - 1:43:37 PM
Last modification on : Friday, February 5, 2021 - 9:24:02 AM
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Mika Kivimaki, Adam Tabak, G David Batty, Archana Singh-Manoux, Markus Jokela, et al.. Hyperglycemia, type 2 diabetes, and depressive symptoms: the British Whitehall II study.. Diabetes Care, American Diabetes Association, 2009, 32 (10), pp.1867-9. ⟨10.2337/dc09-0716⟩. ⟨inserm-00426437⟩



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