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Comment on "Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake".

Nicolas Chartrel 1 Rodrigo Alvear-Perez 2 Jérôme Leprince 1 Xavier Iturrioz 2 Annabelle Reaux-Le Goazigo 2 Valérie Audinot 3 Pascale Chomarat 3 Francis Cogé 3 Olivier Nosjean 3 Marianne Rodriguez 3 Jean-Pierre Galizzi 3 Jean A. Boutin 3 Hubert Vaudry 1 Catherine Llorens-Cortes 2 
2 Neuropeptides centraux et régulations hydrique et cardiovasculaire
UPMC - Université Pierre et Marie Curie - Paris 6, CIRB - Centre interdisciplinaire de recherche en biologie, INSERM - Institut National de la Santé et de la Recherche Médicale : U691
Abstract : Zhang et al. (Research Articles, 11 November 2005, p. 996) reported that obestatin, a peptide derived from the ghrelin precursor, activated the orphan G protein-coupled receptor GPR39. However, we found that I125-obestatin does not bind GPR39 and observed no effects of obestatin on GPR39-transfected cells in various functional assays (cyclic adenosine monophosphate production, calcium mobilization, and GPR39 internalization). Our results indicate that obestatin is not the cognate ligand for GPR39.
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Submitted on : Thursday, October 15, 2009 - 5:03:53 PM
Last modification on : Monday, May 9, 2022 - 11:58:07 AM



Nicolas Chartrel, Rodrigo Alvear-Perez, Jérôme Leprince, Xavier Iturrioz, Annabelle Reaux-Le Goazigo, et al.. Comment on "Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake".. Science, American Association for the Advancement of Science (AAAS), 2007, 315 (5813), 766; author reply 766. ⟨10.1126/science.1135047⟩. ⟨inserm-00424430⟩



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