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Comment on "Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake".

Abstract : Zhang et al. (Research Articles, 11 November 2005, p. 996) reported that obestatin, a peptide derived from the ghrelin precursor, activated the orphan G protein-coupled receptor GPR39. However, we found that I125-obestatin does not bind GPR39 and observed no effects of obestatin on GPR39-transfected cells in various functional assays (cyclic adenosine monophosphate production, calcium mobilization, and GPR39 internalization). Our results indicate that obestatin is not the cognate ligand for GPR39.
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https://www.hal.inserm.fr/inserm-00424430
Contributor : Catherine Llorens Cortes <>
Submitted on : Thursday, October 15, 2009 - 5:03:53 PM
Last modification on : Wednesday, September 23, 2020 - 4:32:32 AM

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Nicolas Chartrel, Rodrigo Alvear-Perez, Jérôme Leprince, Xavier Iturrioz, Annabelle Reaux-Le Goazigo, et al.. Comment on "Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake".. Science, American Association for the Advancement of Science, 2007, 315 (5813), 766; author reply 766. ⟨10.1126/science.1135047⟩. ⟨inserm-00424430⟩

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