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Article Dans Une Revue Journal of the American College of Nutrition Année : 2009

Antioxidant effects of a cinnamon extract in people with impaired fasting glucose that are overweight or obese.

Résumé

OBJECTIVE: To determine the effects of a dried aqueous extract of cinnamon on antioxidant status of people with impaired fasting glucose that are overweight or obese. METHODS: Twenty-two subjects, with impaired fasting blood glucose with BMI ranging from 25 to 45, were enrolled in a double-blind placebo-controlled trial. Subjects were given capsules containing either a placebo or 250 mg of an aqueous extract of cinnamon (Cinnulin PF) two times per day for 12 weeks. Plasma malondialdehyde (MDA) concentrations were assessed using high performance liquid chromatography and plasma antioxidant status was evaluated using ferric reducing antioxidant power (FRAP) assay. Erythrocyte Cu-Zn superoxide (Cu-Zn SOD) activity was measured after hemoglobin precipitation by monitoring the auto-oxidation of pyrogallol and erythrocyte glutathione peroxidase (GPx) activity by established methods. RESULTS: FRAP and plasma thiol (SH) groups increased, while plasma MDA levels decreased in subjects receiving the cinnamon extract. Effects were larger after 12 than 6 weeks. There was also a positive correlation (r = 0.74; p = 0.014) between MDA and plasma glucose. CONCLUSION: This study supports the hypothesis that the inclusion of water soluble cinnamon compounds in the diet could reduce risk factors associated with diabetes and cardiovascular disease.
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Dates et versions

inserm-00422519 , version 1 (07-10-2009)

Identifiants

  • HAL Id : inserm-00422519 , version 1
  • PUBMED : 19571155

Citer

Anne-Marie Roussel, Isabelle Hininger, Rachida Benaraba, Tim N. Ziegenfuss, Richard A. Anderson. Antioxidant effects of a cinnamon extract in people with impaired fasting glucose that are overweight or obese.. Journal of the American College of Nutrition, 2009, 28 (1), pp.16-21. ⟨inserm-00422519⟩

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