Serum bile acids are higher in humans with prior gastric bypass: potential contribution to improved glucose and lipid metabolism. - Archive ouverte HAL Access content directly
Journal Articles Obesity (Silver Spring, Md.) Year : 2009

Serum bile acids are higher in humans with prior gastric bypass: potential contribution to improved glucose and lipid metabolism.

(1) , (2) , (3) , (1) , (4, 5) , (6) , (4, 7) , (4, 7) , (4, 5) , (1, 4) , (8, 9) , (1, 4, 5)
1
2
3
4
5
6
7
8
9

Abstract

The multifactorial mechanisms promoting weight loss and improved metabolism following Roux-en-Y gastric bypass (GB) surgery remain incompletely understood. Recent rodent studies suggest that bile acids can mediate energy homeostasis by activating the G-protein coupled receptor TGR5 and the type 2 thyroid hormone deiodinase. Altered gastrointestinal anatomy following GB could affect enterohepatic recirculation of bile acids. We assessed whether circulating bile acid concentrations differ in patients who previously underwent GB, which might then contribute to improved metabolic homeostasis. We performed cross-sectional analysis of fasting serum bile acid composition and both fasting and post-meal metabolic variables, in three subject groups: (i) post-GB surgery (n = 9), (ii) without GB matched to preoperative BMI of the index cohort (n = 5), and (iii) without GB matched to current BMI of the index cohort (n = 10). Total serum bile acid concentrations were higher in GB (8.90 +/- 4.84 micromol/l) than in both overweight (3.59 +/- 1.95, P = 0.005, Ov) and severely obese (3.86 +/- 1.51, P = 0.045, MOb). Bile acid subfractions taurochenodeoxycholic, taurodeoxycholic, glycocholic, glycochenodeoxycholic, and glycodeoxycholic acids were all significantly higher in GB compared to Ov (P < 0.05). Total bile acids were inversely correlated with 2-h post-meal glucose (r = -0.59, P < 0.003) and fasting triglycerides (r = -0.40, P = 0.05), and positively correlated with adiponectin (r = -0.48, P < 0.02) and peak glucagon-like peptide-1 (GLP-1) (r = 0.58, P < 0.003). Total bile acids strongly correlated inversely with thyrotropic hormone (TSH) (r = -0.57, P = 0.004). Together, our data suggest that altered bile acid levels and composition may contribute to improved glucose and lipid metabolism in patients who have had GB.

Dates and versions

inserm-00420817 , version 1 (29-09-2009)

Identifiers

Cite

Mary-Elizabeth Patti, Sander M. Houten, Antonio C. Bianco, Raquel Bernier, P Reed Larsen, et al.. Serum bile acids are higher in humans with prior gastric bypass: potential contribution to improved glucose and lipid metabolism.. Obesity (Silver Spring, Md.), 2009, 17 (9), pp.1671-7. ⟨10.1038/oby.2009.102⟩. ⟨inserm-00420817⟩
159 View
0 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More