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Journal Articles Transplantation Proceedings Year : 2007

Effect of FTY720 on apoptosis of smooth muscle cells.

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BACKGROUND: Hyperproliferation of smooth muscle cells (SMCs) plays a key role in allograft arteriosclerosis. This prompted us to investigate the effect of the novel immune modulator and synthetic sphingolipid FTY720 on apoptosis of SMCs. METHODS: Rabbit SMC cultures were treated with FTY720 and apoptosis and necrosis were detected by fluorescence microscopy. RESULTS: We investigated dose- and time-dependent effects of FTY720 and found that clinically relevant low doses of FTY720 (<1 micromol/L) did not induce apoptosis, whereas 10 micromol/L FTY720 induced apoptosis after 48 hours incubation. CONCLUSION: At doses of FTY720 used in clinics for treatment of renal allografts and multiple sclerosis. FTY720 did not induce SMC apoptosis.

Dates and versions

inserm-00420472 , version 1 (29-09-2009)



Torsten Böhler, J. Guillebaud, Lucien Etienne, Cindy Canivet, Nassim Kamar, et al.. Effect of FTY720 on apoptosis of smooth muscle cells.. Transplantation Proceedings, 2007, 39 (8), pp.2624-6. ⟨10.1016/j.transproceed.2007.08.012⟩. ⟨inserm-00420472⟩
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