iNKT cell development is orchestrated by different branches of TGF-beta signaling. - Archive ouverte HAL Access content directly
Journal Articles Journal of Experimental Medicine Year : 2009

iNKT cell development is orchestrated by different branches of TGF-beta signaling.

(1, 2) , (3) , (4) , (5) , (2) , (6) , (3) , (5) , (5, 7) , (3) , (3) , (4) , (2) , (3, 5)
1
2
3
4
5
6
7

Abstract

Invariant natural killer T (iNKT) cells constitute a distinct subset of T lymphocytes exhibiting important immune-regulatory functions. Although various steps of their differentiation have been well characterized, the factors controlling their development remain poorly documented. Here, we show that TGF-beta controls the differentiation program of iNKT cells. We demonstrate that TGF-beta signaling carefully and specifically orchestrates several steps of iNKT cell development. In vivo, this multifaceted role of TGF-beta involves the concerted action of different pathways of TGF-beta signaling. Whereas the Tif-1gamma branch controls lineage expansion, the Smad4 branch maintains the maturation stage that is initially repressed by a Tif-1gamma/Smad4-independent branch. Thus, these three different branches of TGF-beta signaling function in concert as complementary effectors, allowing TGF-beta to fine tune the iNKT cell differentiation program.

Dates and versions

inserm-00420389 , version 1 (28-09-2009)

Identifiers

Cite

Jean-Marc Doisne, Laurent Bartholin, Kai-Ping Yan, Céline N. Garcia, Nadia Duarte, et al.. iNKT cell development is orchestrated by different branches of TGF-beta signaling.. Journal of Experimental Medicine, 2009, 206 (6), pp.1365-78. ⟨10.1084/jem.20090127⟩. ⟨inserm-00420389⟩
226 View
0 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More