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iNKT cell development is orchestrated by different branches of TGF-beta signaling.

Abstract : Invariant natural killer T (iNKT) cells constitute a distinct subset of T lymphocytes exhibiting important immune-regulatory functions. Although various steps of their differentiation have been well characterized, the factors controlling their development remain poorly documented. Here, we show that TGF-beta controls the differentiation program of iNKT cells. We demonstrate that TGF-beta signaling carefully and specifically orchestrates several steps of iNKT cell development. In vivo, this multifaceted role of TGF-beta involves the concerted action of different pathways of TGF-beta signaling. Whereas the Tif-1gamma branch controls lineage expansion, the Smad4 branch maintains the maturation stage that is initially repressed by a Tif-1gamma/Smad4-independent branch. Thus, these three different branches of TGF-beta signaling function in concert as complementary effectors, allowing TGF-beta to fine tune the iNKT cell differentiation program.
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Contributor : Maité Peney <>
Submitted on : Monday, September 28, 2009 - 6:12:31 PM
Last modification on : Wednesday, November 25, 2020 - 2:52:07 PM

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Jean-Marc Doisne, Laurent Bartholin, Kai-Ping Yan, Céline Garcia, Nadia Duarte, et al.. iNKT cell development is orchestrated by different branches of TGF-beta signaling.. Journal of Experimental Medicine, Rockefeller University Press, 2009, 206 (6), pp.1365-78. ⟨10.1084/jem.20090127⟩. ⟨inserm-00420389⟩



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