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Journal articles
Endothelial basement membrane laminin alpha5 selectively inhibits T lymphocyte extravasation into the brain.
Chuan Wu
1
Fredrik Ivars
2
Per Anderson
2
Rupert Hallmann
1
Dietmar Vestweber
3
Per Nilsson
4
Horst Robenek
5
Karl Tryggvason
6
Jian Song
1
Eva Korpos
1
Karin Loser
7
Stefan Beissert
7
Elisabeth Georges-Labouesse
8
Lydia Sorokin
1
Elisabeth Georges-Labouesse 8
Author
Lydia M. Sorokin 1
Author
1
Institute for Physiological Chemistry and Pathobiochemistry (Germany)
- WWU - Westfälische Wilhelms-Universität Münster (Universität Münster Schlossplatz 2 48149 Münster - Germany)
2
Section for Immunology, Department of Experimental Medical Science (Sweden)
- Lund University [Lund] (Paradisgatan 2 Box 117, SE-221 00 Lund - Sweden)
4
Radiation Physics (Sweden)
- Lund University [Lund] (Paradisgatan 2 Box 117, SE-221 00 Lund - Sweden)
5
Leibniz Institute for Arterosclerosis Research (Germany)
- WWU - Westfälische Wilhelms-Universität Münster (Universität Münster Schlossplatz 2 48149 Münster - Germany)
6
Department of Medical Biochemistry and Biophysics (Sweden)
- Karolinska Institutet [Stockholm] (Solnavägen 1, 171 77 Solna Stockholm - Sweden)
7
Department of Dermatology (Germany)
- WWU - Westfälische Wilhelms-Universität Münster (Universität Münster Schlossplatz 2 48149 Münster - Germany)
8
IGBMC - Institut de génétique et biologie moléculaire et cellulaire (I.G.B.M.C, Parc D'Innovation 1 Rue Laurent Fries - BP 10142 67404 ILLKIRCH CEDEX - France)
- Université Louis Pasteur - Strasbourg I (France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U596 (101, rue de Tolbiac, 75013 Paris - France)
- CNRS - Centre National de la Recherche Scientifique : UMR7104 (France)
Abstract : Specific inhibition of the entry of encephalitogenic T lymphocytes into the central nervous system in multiple sclerosis would provide a means of inhibiting disease without compromising innate immune responses. We show here that targeting lymphocyte interactions with endothelial basement membrane laminins provides such a possibility. In mouse experimental autoimmune encephalomyelitis, T lymphocyte extravasation correlates with sites expressing laminin alpha4 and small amounts of laminin alpha5. In mice lacking laminin alpha4, laminin alpha5 is ubiquitously expressed along the vascular tree, resulting in marked and selective reduction of T lymphocyte infiltration into the brain and reduced disease susceptibility and severity. Vessel phenotype and immune response were not affected in these mice. Rather, laminin alpha5 directly inhibited integrin alpha(6)beta(1)-mediated migration of T lymphocytes through laminin alpha4. The data indicate that T lymphocytes use mechanisms distinct from other immune cells to penetrate the endothelial basement membrane barrier, permitting specific targeting of this immune cell population.
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Journal articles
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https://www.hal.inserm.fr/inserm-00420073
Contributor : Maité Peney <>
Submitted on : Monday, September 28, 2009 - 10:14:34 AM
Last modification on : Thursday, April 23, 2020 - 2:26:26 PM
Contributor : Maité Peney <>
Submitted on : Monday, September 28, 2009 - 10:14:34 AM
Last modification on : Thursday, April 23, 2020 - 2:26:26 PM
Identifiers
- HAL Id : inserm-00420073, version 1
- DOI : 10.1038/nm.1957
- PUBMED : 19396173
Collections
INSERM | CNRS | IGBMC | SITE-ALSACE
Citation
Chuan Wu, Fredrik Ivars, Per Anderson, Rupert Hallmann, Dietmar Vestweber, et al.. Endothelial basement membrane laminin alpha5 selectively inhibits T lymphocyte extravasation into the brain.. Nature Medicine, Nature Publishing Group, 2009, 15 (5), pp.519-27. ⟨10.1038/nm.1957⟩. ⟨inserm-00420073⟩
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