S. Chen and G. Parmigiani, Penetrance, Journal of Clinical Oncology, vol.25, issue.11, pp.1329-1362, 2007.
DOI : 10.1200/JCO.2006.09.1066

A. Antoniou, O. Sinilnikova, J. Simard, M. Léoné, M. Dumont et al., RAD51 135G???C Modifies Breast Cancer Risk among BRCA2 Mutation Carriers: Results from a Combined Analysis of 19 Studies, The American Journal of Human Genetics, vol.81, issue.6, pp.1186-200, 2007.
DOI : 10.1086/522611

A. Antoniou, A. Spurdle, O. Sinilnikova, S. Healey, K. Pooley et al., Common Breast Cancer-Predisposition Alleles Are Associated with Breast Cancer Risk in BRCA1 and BRCA2 Mutation Carriers, The American Journal of Human Genetics, vol.82, issue.4, pp.937-985, 2008.
DOI : 10.1016/j.ajhg.2008.02.008

F. Eisinger, B. Bressac, D. Castaigne, P. Cottu, J. Lansac et al., Identification et prise en charge des prédispositions héréditaires aux cancers du sein et de l'ovaire, Bull Cancer, vol.91, pp.219-256, 2004.
DOI : 10.1016/j.patbio.2006.02.002

V. Bonadona, O. Sinilnikova, S. Chopin, A. Antoniou, H. Mignotte et al., Contribution ofBRCA1 andBRCA2 germ-line mutations to the incidence of breast cancer in young women: Results from a prospective population-based study in France, Genes, Chromosomes and Cancer, vol.378, issue.4, pp.404-417, 2005.
DOI : 10.1002/gcc.20199

F. Alarcon, C. Bourgain, M. Gauthier-villars, V. Planté-bordeneuve, D. Stoppa-lyonnet et al., PEL: an unbiased method for estimating age-dependent genetic disease risk from pedigree data unselected for family history, Genetic Epidemiology, vol.9, issue.5, pp.379-85, 2009.
DOI : 10.1002/gepi.20390

URL : https://hal.archives-ouvertes.fr/inserm-00358140

P. Møller, A. Hagen, J. Apold, L. Maehle, N. Clark et al., Genetic epidemiology of BRCA mutations ??? family history detects less than 50% of the mutation carriers, European Journal of Cancer, vol.43, issue.11, pp.1713-1720, 2007.
DOI : 10.1016/j.ejca.2007.04.023

M. Robson and K. Offit, Management of an Inherited Predisposition to Breast Cancer, New England Journal of Medicine, vol.357, issue.2, pp.154-62, 2007.
DOI : 10.1056/NEJMcp071286

H. Vasen, J. Mecklin, P. Meera-khan, and H. Lynch, The International Collaborative Group on Hereditary Non-Polyposis Colorectal Cancer (ICG-HNPCC), Diseases of the Colon & Rectum, vol.34, issue.5, pp.424-429, 1991.
DOI : 10.1007/BF02053699

M. Rodrigues-bigas, C. Boland, S. Hamilton, D. Henson, J. Jass et al., A National Cancer Institute Workshop on Hereditary Nonpolyposis Colorectal Cancer Syndrome: Meeting Highlights and Bethesda Guidelines, JNCI Journal of the National Cancer Institute, vol.89, issue.23, pp.1758-62, 1997.
DOI : 10.1093/jnci/89.23.1758

H. Vasen, P. Watson, J. Mecklin, and H. Lynch, New clinical criteria for hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome) proposed by the International Collaborative Group on HNPCC???, Gastroenterology, vol.116, issue.6, pp.1453-1461, 1999.
DOI : 10.1016/S0016-5085(99)70510-X

C. Bonaïti-pellié, F. Eisinger, J. Feingold, . Frébourg, S. Grandjouan et al., Pr??dispositions h??r??ditaires au cancer colorectal, Prédispositions héréditaires au cancer colorectal, pp.701-711, 2005.
DOI : 10.1016/S0399-8320(05)82159-1

N. Lindor, G. Petersen, D. Hadley, A. Kinney, S. Miesfeldt et al., Recommendations for the Care of Individuals With an Inherited Predisposition to Lynch Syndrome, JAMA, vol.296, issue.12, pp.1507-1524, 2006.
DOI : 10.1001/jama.296.12.1507

H. Vasen, G. Möslein, A. Alonso, I. Berntein, L. Bertario et al., Guidelines for the clinical management of Lynch syndrome (hereditary non-polyposis cancer), Journal of Medical Genetics, vol.44, issue.6, pp.353-62, 2007.
DOI : 10.1136/jmg.2007.048991

J. Mecklin, M. Aarnio, E. Läärä, M. Kairaluoma, K. Pylvänäinen et al., Development of Colorectal Tumors in Colonoscopic Surveillance in Lynch Syndrome, Gastroenterology, vol.133, issue.4, pp.1093-1101, 2007.
DOI : 10.1053/j.gastro.2007.08.019

H. Järvinen, M. Aarnio, H. Mustonen, K. Aktan-collan, L. Aaltonen et al., Controlled 15-year trial on screening for colorectal cancer in families with hereditary nonpolyposis colorectal cancer, Gastroenterology, vol.118, issue.5, pp.829-863, 2000.
DOI : 10.1016/S0016-5085(00)70168-5

L. Renkonen-sinisalo, R. Bützow, A. Leminen, P. Lehtovirta, J. Mecklin et al., Surveillance for endometrial cancer in hereditary nonpolyposis colorectal cancer syndrome, International Journal of Cancer, vol.16, issue.4, pp.821-825, 2007.
DOI : 10.1002/ijc.22446

K. Aktan-collan, A. Haukkala, J. Mecklin, A. Uutela, and H. Kääriäinen, Psychological consequences of predictive genetic testing for hereditary non-polyposis colorectal cancer (HNPCC): A prospective follow-up study, International Journal of Cancer, vol.86, issue.4, pp.608-619, 2001.
DOI : 10.1002/ijc.1372

E. Gritz, S. Peterson, S. Vernon, S. Marani, W. Baile et al., Psychological Impact of Genetic Testing for Hereditary Nonpolyposis Colorectal Cancer, Journal of Clinical Oncology, vol.23, issue.9, pp.1902-1912, 2005.
DOI : 10.1200/JCO.2005.07.102

V. Collins, B. Meiser, O. Ukoumunne, C. Gaff, S. John et al., The impact of predictive genetic testing for hereditary nonpolyposis colorectal cancer: three years after testing, Genetics in Medicine, vol.354, issue.5, pp.290-297, 2007.
DOI : 10.1097/GIM.0b013e31804b45db

B. Meiser, V. Collins, R. Warren, C. Gaff, S. John et al., Psychological impact of genetic testing for hereditary non-polyposis colorectal cancer, Clinical Genetics, vol.5, issue.4, pp.502-511, 2004.
DOI : 10.1111/j.1399-0004.2004.00339.x

S. Shiloh, L. Koehly, J. Jenkins, J. Martin, and D. Hadley, Monitoring coping style moderates emotional reactions to genetic testing for hereditary nonpolyposis colorectal cancer: a longitudinal study, Psycho-Oncology, vol.32, issue.5, pp.746-55, 2008.
DOI : 10.1002/pon.1338

V. Christophe, T. Leroy, C. Adenis, M. Reich, and P. Vennin, Information spreading about hereditary carriage of a BRCA1/2 mutation and ovarian cancer and rate of consultation of the concerned relatives, Bull Cancer, vol.95, pp.395-402, 2008.

M. Schwartz, C. Lerman, B. Brogan, B. Peshkin, C. Halbert et al., Counseling and Testing on Newly Diagnosed Breast Cancer Patients, Journal of Clinical Oncology, vol.22, issue.10, pp.1823-1832, 2004.
DOI : 10.1200/JCO.2004.04.086

L. Lodder, P. Frets, R. Trijsburg, E. Meijers-heijboer, J. Klijn et al., Psychological impact of receiving aBRCA1/BRCA2 test result, American Journal of Medical Genetics, vol.67, issue.1, pp.15-24, 2001.
DOI : 10.1002/1096-8628(20010101)98:1<15::AID-AJMG1014>3.0.CO;2-0

F. Eisinger, J. Jacquemier, C. Charpin, D. Stoppa-lyonnet, B. Bressac-de-paillerets et al., Mutations at BRCA1: the medullary breast carcinoma revisited, Cancer Res, vol.58, pp.1588-92, 1998.

J. Peto, N. Collins, R. Barfoot, S. Seal, W. Warren et al., Prevalence of BRCA1 and BRCA2 Gene Mutations in Patients With Early-Onset Breast Cancer, JNCI Journal of the National Cancer Institute, vol.91, issue.11, pp.943-952, 1999.
DOI : 10.1093/jnci/91.11.943

A. Antoniou, P. Pharoah, P. Smith, and D. Easton, The BODICEA model of genetic susceptibility to breast and ovarian cancer, Br J Cancer, vol.91, pp.1580-90, 2004.

M. Litwiniuk, K. Roznowski, V. Filas, D. Godlewski, M. Stawicka et al., Expression of estrogen receptor beta in the breast carcinoma of BRCA1 mutation carriers, BMC Cancer, vol.13, issue.1, p.100, 2008.
DOI : 10.1158/1078-0432.CCR-06-1823

D. Atchley, C. Albarracin, A. Lopez, V. Valero, C. Amos et al., -Negative Breast Cancer, Journal of Clinical Oncology, vol.26, issue.26, pp.4282-4290, 2008.
DOI : 10.1200/JCO.2008.16.6231

URL : https://hal.archives-ouvertes.fr/hal-00894139

O. Jørgensen, O. Kronborg, and C. Fenger, The Funen Adenoma Follow-Up Study Characteristics of Patients and Initial Adenomas in Relation to Severe Dysplasia, Scandinavian Journal of Gastroenterology, vol.32, issue.3, pp.239-282, 1993.
DOI : 10.1136/jcp.35.8.830

A. Neugut, J. Jacobson, H. Ahsan, J. Santos, G. Garbowski et al., Incidence and recurrence rates of colorectal adenomas: A prospective study, Gastroenterology, vol.108, issue.2, pp.402-410, 1995.
DOI : 10.1016/0016-5085(95)90066-7

D. Lieberman, D. Weiss, J. Bond, D. Ahnen, H. Garewal et al., Use of Colonoscopy to Screen Asymptomatic Adults for Colorectal Cancer, New England Journal of Medicine, vol.343, issue.3, pp.162-170, 2000.
DOI : 10.1056/NEJM200007203430301

B. Gold, T. Kirchhoff, S. Stefanov, J. Lautenberger, A. Viale et al., Genome-wide association study provides evidence for a breast cancer risk locus at 6q22.33, Proceedings of the National Academy of Sciences, vol.105, issue.11, pp.4340-4345, 2008.
DOI : 10.1073/pnas.0800441105

L. Si-on-appliquait-uniquement-les-critères-familiaux and 4. Sensibilité-serait-donc-de, Si l'on restreint les critères familiaux aux CCR seuls, le nombre de cas présentant les critères en population générale peut être estimé à 590 dont 340 sont mutés MMR et 250 ne le sont pas

A. Antoniou, P. Pharoah, G. Mcmullan, N. Day, M. Stratton et al., A comprehensive model for familial breast cancer incorporating BRCA1, BRCA2 and other genes, British Journal of Cancer, vol.60, issue.1, pp.76-83, 2002.
DOI : 10.1086/318181

. Inserm-fnclcc, Risques héréditaires de cancers du sein et de l'ovaire. Quelles prises en charge ? Paris : Inserm, 1998.

S. Pennec, La place des familles a quatre generations en France, Population (French Edition), vol.51, issue.1, pp.31-60, 1996.
DOI : 10.2307/1534657

A. Bélot, P. Grosclaude, N. Bossard, E. Jougla, E. Benhamou et al., Cancer incidence and mortality in France over the period 1980???2005, Revue d'??pid??miologie et de Sant?? Publique, vol.56, issue.3, pp.159-75, 2008.
DOI : 10.1016/j.respe.2008.03.117

X. Llor, E. Pons, R. Xicola, A. Castells, C. Alenda et al., Differential Features of Colorectal Cancers Fulfilling Amsterdam Criteria without Involvement of the Mutator Pathway, Clinical Cancer Research, vol.11, issue.20, pp.7304-7314, 2005.
DOI : 10.1158/1078-0432.CCR-05-0965

R. Salovaara, A. Loukola, P. Kristo, H. Kääriäinen, H. Ahtola et al., Population-Based Molecular Detection of Hereditary Nonpolyposis Colorectal Cancer, Journal of Clinical Oncology, vol.18, issue.11, pp.2193-200, 2000.
DOI : 10.1200/JCO.2000.18.11.2193