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Plasmacytoid dendritic cells capture and cross-present viral antigens from influenza-virus exposed cells.

Abstract : Among the different subsets of dendritic cells (DC), plasmacytoid dendritic cells (PDC) play a unique role in secreting large amounts of type I interferons upon viral stimulation, but their efficiency as antigen-presenting cells has not been completely characterized. We show here, by flow cytometry, with human primary blood PDC and with a PDC cell line, that PDC display poor endocytic capacity for soluble or cellular antigens when compared to monocyte-derived myeloid DC. However, immature PDC efficiently take up cellular material from live influenza-exposed cells, subsequently mature and cross-present viral antigens very efficiently to specific CD8+ T cells. Therefore, during viral infection PDC not only secrete immunomodulatory cytokines, but also recognize infected cells and function as antigen cross-presenting cells to trigger the anti-viral immune response.
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https://www.hal.inserm.fr/inserm-00419345
Contributor : Laurence Chaperot <>
Submitted on : Wednesday, September 23, 2009 - 1:37:14 PM
Last modification on : Friday, November 6, 2020 - 4:04:53 AM
Long-term archiving on: : Tuesday, June 15, 2010 - 10:12:33 PM

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Gabrielle Lui, Olivier Manches, Juliette Angel, Jean-Paul Molens, Laurence Chaperot, et al.. Plasmacytoid dendritic cells capture and cross-present viral antigens from influenza-virus exposed cells.. PLoS ONE, Public Library of Science, 2009, 4 (9), pp.e7111. ⟨10.1371/journal.pone.0007111⟩. ⟨inserm-00419345⟩

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