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Do membrane undulations help cells probe the world?

Abstract : Cells sense physical properties of their environment including substratum rigidity, roughness, and topography of recognition sites. The cell surface displays continuous deformations of nanometer-scale amplitude and Hz frequency. Recent results support the hypothesis that these surface undulations constitute a powerful strategy for the rapid acquisition of environmental cues: transient contact with surroundings generates forces of piconewton intensity as a result of rapid formation and dissociation of intermolecular bonds. The combination of binding and steric forces is expected to drive conformational changes and lateral reorganization of membrane biomolecules, thus generating signaling cascades. We propose that spontaneous membrane mobility shapes the initial information generated by cell-to-surface contacts, and thereby biases later consequences of these interactions.
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https://www.hal.inserm.fr/inserm-00416601
Contributor : Pierre Bongrand <>
Submitted on : Monday, September 14, 2009 - 5:56:49 PM
Last modification on : Wednesday, August 19, 2020 - 12:08:05 PM
Long-term archiving on: : Tuesday, June 15, 2010 - 7:56:56 PM

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Anne Pierres, Virginie Monnet-Corti, Anne-Marie Benoliel, Pierre Bongrand. Do membrane undulations help cells probe the world?. Trends in Cell Biology, Elsevier, 2009, 19 (9), pp.428-33. ⟨10.1016/j.tcb.2009.05.009⟩. ⟨inserm-00416601⟩

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