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Journal Articles Molecular and Cellular Biochemistry Year : 2008

Protein kinase CK2 and cell polarity.

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Abstract

There is increasing evidence that protein kinase CK2 is involved, among a wide variety of cellular processes, in the maintenance of mammalian cell morphology and cell polarity. Here, we show that in epithelial cells, a fraction of CK2 is associated to the plasma membrane and that this localization is controlled by cell-matrix interactions. In addition, inhibition of CK2 activity in mammary epithelial cells (MCF10A), using either the specific CK2 inhibitor TBB or siRNA-mediated CK2beta knockdown, induced differential phenotypes revealing an important role of this enzyme in epithelial cell morphology.

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inserm-00413236 , version 1 (03-09-2009)

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Alexandre Deshière, Nathalie Theis-Febvre, Véronique Martel, Claude Cochet, Odile Filhol. Protein kinase CK2 and cell polarity.. Molecular and Cellular Biochemistry, 2008, 316 (1-2), pp.107-13. ⟨10.1007/s11010-008-9845-y⟩. ⟨inserm-00413236⟩

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