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Protein kinase CK2 and cell polarity.

Abstract : There is increasing evidence that protein kinase CK2 is involved, among a wide variety of cellular processes, in the maintenance of mammalian cell morphology and cell polarity. Here, we show that in epithelial cells, a fraction of CK2 is associated to the plasma membrane and that this localization is controlled by cell-matrix interactions. In addition, inhibition of CK2 activity in mammary epithelial cells (MCF10A), using either the specific CK2 inhibitor TBB or siRNA-mediated CK2beta knockdown, induced differential phenotypes revealing an important role of this enzyme in epithelial cell morphology.
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Contributor : Claude Cochet <>
Submitted on : Thursday, September 3, 2009 - 3:32:34 PM
Last modification on : Friday, November 6, 2020 - 4:12:24 AM

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Alexandre Deshière, Nathalie Theis-Febvre, Véronique Martel, Claude Cochet, Odile Filhol. Protein kinase CK2 and cell polarity.. Molecular and Cellular Biochemistry, Springer Verlag, 2008, 316 (1-2), pp.107-13. ⟨10.1007/s11010-008-9845-y⟩. ⟨inserm-00413236⟩



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