Abstract : Protein-protein interactions have a key role in transduction pathways that regulate many cellular functions. Structural and functional properties of protein-protein interface are now better understood, therefore offering attractive opportunities for therapeutic intervention. Developping small molecules that modulate protein-protein interactions is challenging. Nethertheless, significant progress in this endeavour has been made on several fronts. Here, we use few illustrative examples to summarize recent work in this emerging field.
http://www.hal.inserm.fr/inserm-00413234
Contributeur : Claude Cochet
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Soumis le : jeudi 3 septembre 2009 - 15:22:29
Dernière modification le : jeudi 3 septembre 2009 - 15:26:48
