Coat variation in the domestic dog is governed by variants in three genes. - Archive ouverte HAL Access content directly
Journal Articles Science Year : 2009

Coat variation in the domestic dog is governed by variants in three genes.

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Abstract

Coat color and type are essential characteristics of domestic dog breeds. Although the genetic basis of coat color has been well characterized, relatively little is known about the genes influencing coat growth pattern, length, and curl. We performed genome-wide association studies of more than 1000 dogs from 80 domestic breeds to identify genes associated with canine fur phenotypes. Taking advantage of both inter- and intrabreed variability, we identified distinct mutations in three genes, RSPO2, FGF5, and KRT71 (encoding R-spondin-2, fibroblast growth factor-5, and keratin-71, respectively), that together account for most coat phenotypes in purebred dogs in the United States. Thus, an array of varied and seemingly complex phenotypes can be reduced to the combinatorial effects of only a few genes.

Dates and versions

inserm-00412221 , version 1 (01-09-2009)

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Edouard Cadieu, Mark Neff, Pascale Quignon, Kari Walsh, Kevin Chase, et al.. Coat variation in the domestic dog is governed by variants in three genes.. Science, 2009, 326 (5949), pp.150-3. ⟨10.1126/science.1177808⟩. ⟨inserm-00412221⟩
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