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Journal Articles Trends in Neurosciences Year : 2005

Subcortical loops through the basal ganglia.


Parallel, largely segregated, closed-loop projections are an important component of cortical-basal ganglia-cortical connectional architecture. Here, we present the hypothesis that such loops involving the neocortex are neither novel nor the first evolutionary example of closed-loop architecture involving the basal ganglia. Specifically, we propose that a phylogenetically older, closed-loop series of subcortical connections exists between the basal ganglia and brainstem sensorimotor structures, a good example of which is the midbrain superior colliculus. Insofar as this organization represents a general feature of brain architecture, cortical and subcortical inputs to the basal ganglia might act independently, co-operatively or competitively to influence the mechanisms of action selection.

Dates and versions

inserm-00411012 , version 1 (25-08-2009)



John G. Mchaffie, Terrence R. Stanford, Barry E. Stein, Véronique Coizet, Peter Redgrave. Subcortical loops through the basal ganglia.. Trends in Neurosciences, 2005, 28 (8), pp.401-7. ⟨10.1016/j.tins.2005.06.006⟩. ⟨inserm-00411012⟩


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