Social sciences team Annabel Desgrées-du-Loû, Annick Tijou-Traoré, Benjamin Zanou Scientific Committee: Stéphane Blanche Composition of the Vertical Transmission Study Group. Study investigators ,
Victoria Sithole (Community Advisory Board) and the study investigators. Data monitoring and Safety Committee: Cathy Wilfert (chair, Elizabeth Glaser Pediatric AIDS foundation), Carl Lombard (statistician, Medical Research Council, South Africa) Francis Crawley (Good Clinical Practice Alliance) Data management: Cookie Govender, Londiwe Mthethwa and team. Clinical team: Thembi Blose, Nqobile Mkhwanazi, Dumo Mkwanazi and team. Field team: Zanele Fakude, Samukelisiwe Dube and team. Laboratory team, Nono Simelela ,
WHO estimates of the causes of death in children, The Lancet, vol.365, issue.9465, pp.1147-1152, 2005. ,
DOI : 10.1016/S0140-6736(05)71877-8
Is there a difference in the efficacy of peripartum antiretroviral regimens in reducing mother-to-child transmission of HIV in Africa?, AIDS, vol.19, issue.16, pp.1865-1875, 2005. ,
DOI : 10.1097/01.aids.0000188423.02786.55
Late postnatal transmission of HIV-1 in breast-fed children: an individual patient data meta-analysis, International Transmission Study Group (BHITS) J Infect Dis, vol.189, pp.2154-2166, 2004. ,
Prevention of postnatal HIV infection: infant feeding and antiretroviral interventions, Current Opinion in HIV and AIDS, vol.2, issue.5, pp.361-366, 2007. ,
DOI : 10.1097/COH.0b013e3282cecef4
URL : https://hal.archives-ouvertes.fr/inserm-00168585
Mother-to-child transmission of HIV-1 infection during exclusive breastfeeding: the first six months of life, Lancet, vol.369, pp.1607-1616, 2007. ,
Influence of Infant Feeding Patterns on Early Mother-to-Child Transmission of HIV-1 in Durban, South Africa, Annals of the New York Academy of Sciences, vol.353, issue.1, pp.471-476, 1999. ,
DOI : 10.1111/j.1749-6632.2000.tb05482.x
Early exclusive breastfeeding reduces the risk of postnatal HIV-1 transmission and increases HIV-free survival, AIDS, vol.19, issue.7, pp.699-708, 2005. ,
DOI : 10.1097/01.aids.0000166093.16446.c9
Postnatal transmission of HIV-1 after a maternal short-course zidovudine peripartum regimen in West Africa, AIDS, vol.17, issue.10, pp.1493-1501, 2003. ,
DOI : 10.1097/00002030-200307040-00010
Late Postnatal Transmission of HIV???1 and Associated Factors, The Journal of Infectious Diseases, vol.196, issue.1, pp.10-14, 2007. ,
DOI : 10.1086/518511
Acceptability of Exclusive Breast-Feeding With Early Cessation to Prevent HIV Transmission Through Breast Milk, ANRS 1201/1202 Ditrame Plus, Abidjan, C??te d??Ivoire, ANRS 1201/1202 Ditrame Plus, pp.600-608, 2005. ,
DOI : 10.1097/01.qai.0000171726.17436.82
Two-Year Morbidity???Mortality and Alternatives to Prolonged Breast-Feeding among Children Born to HIV-Infected Mothers in C??te d'Ivoire, PLoS Medicine, vol.296, issue.1, p.17, 2007. ,
DOI : 10.1371/journal.pmed.0040017.sd001
Field efficacy of Zidovudine, Lamivudine and single-dose Nevirapine to prevent peripartum transmission of HIV. The ANRS 1201/1202 Ditrame Plus study, AIDS, vol.19, pp.309-318, 2005. ,
URL : https://hal.archives-ouvertes.fr/inserm-00193079
Pregnancy Outcomes in HIV-Infected and Uninfected Women in Rural and Urban South Africa, JAIDS Journal of Acquired Immune Deficiency Syndromes, vol.44, issue.3, pp.321-328, 2007. ,
DOI : 10.1097/QAI.0b013e31802ea4b0
Traditional reviews, meta-analyses and pooled analyses in epidemiology, International Journal of Epidemiology, vol.28, issue.1, pp.1-9, 1999. ,
DOI : 10.1093/ije/28.1.1
Infant feeding counselling for HIV-infected and uninfected women: appropriateness of choice and practice, Bulletin of the World Health Organization, vol.85, issue.4, pp.289-296, 2007. ,
DOI : 10.2471/BLT.06.032441
Acceptability of Formula-Feeding to Prevent HIV Postnatal Transmission, Abidjan, C??te d??Ivoire, JAIDS Journal of Acquired Immune Deficiency Syndromes, vol.44, issue.1, pp.77-86, 2007. ,
DOI : 10.1097/01.qai.0000243115.37035.97
Maternal recall of exclusive breast feeding duration, Archives of Disease in Childhood, vol.88, issue.9, pp.778-783, 2003. ,
DOI : 10.1136/adc.88.9.778
Collection of standardized information on infant feeding in the context of mother-to-child transmission of HIV, Statistics in Medicine, vol.70, issue.23, pp.3525-3537, 2001. ,
DOI : 10.1002/sim.1092
Breastfeeding counselling, a training course: world Health Organization & United Nations Children's Fund, 1993. ,
Early diagnosis of paediatric HIV-1 infection among African breast-fed children using a quantitative plasma HIV RNA assay, AIDS, vol.15, issue.14, pp.1849-1856, 2001. ,
DOI : 10.1097/00002030-200109280-00015
Transfer and Evaluation of an Automated, Low-Cost Real-Time Reverse Transcription-PCR Test for Diagnosis and Monitoring of Human Immunodeficiency Virus Type 1 Infection in a West African Resource-Limited Setting, Journal of Clinical Microbiology, vol.43, issue.6, pp.2709-2717, 2005. ,
DOI : 10.1128/JCM.43.6.2709-2717.2005
Quantification of human immunodeficiency virus type 1 RNA from dried plasma spots collected on filter paper, J Clin Microbiol, vol.35, pp.2795-2801, 1997. ,
Estimating the efficacy of interventions to prevent mother-to-child transmission of HIV in breast-feeding populations: development of a consensus methodology, Statistics in Medicine, vol.53, issue.23, pp.3539-3556, 2001. ,
DOI : 10.1002/sim.1076
Estimating the Efficacy of Interventions to Prevent Mother-to-Child Transmission of Human Immunodeficiency Virus in Breastfeeding Populations: Comparing Statistical Methods, American Journal of Epidemiology, vol.158, issue.6, pp.596-605, 2003. ,
DOI : 10.1093/aje/kwg188
URL : https://hal.archives-ouvertes.fr/inserm-00263550
Analysis of survival data, 1984. ,
Nonparametric Estimation from Incomplete Observations, Journal of the American Statistical Association, vol.37, issue.282, pp.457-481, 1958. ,
DOI : 10.1214/aoms/1177731566
PHMPL: a computer program for hazard estimation using a penalized likelihood method with interval-censored and left-truncated data, Computer Methods and Programs in Biomedicine, vol.60, issue.3, pp.225-231, 1999. ,
DOI : 10.1016/S0169-2607(99)00018-8
URL : https://hal.archives-ouvertes.fr/inserm-00182450
Mode of infant feeding and HIV infection in children in a program for prevention of mother-to-child transmission in Uganda, AIDS, vol.19, issue.4, pp.433-437, 2005. ,
DOI : 10.1097/01.aids.0000161773.29029.c0
Effect of Breastfeeding and Formula Feeding on Transmission of HIV-1, JAMA, vol.283, issue.9, pp.1167-1174, 2000. ,
DOI : 10.1001/jama.283.9.1167
Operational effectiveness of single-dose nevirapine in preventing mother-to-child transmission of HIV, Bulletin of the World Health Organization, vol.85, issue.6, pp.466-473, 2007. ,
DOI : 10.2471/BLT.06.033639
Intrapartum and neonatal single-dose nevirapine compared with zidovudine for prevention of mother-to-child transmission of HIV-1 in Kampala, Uganda: HIVNET 012 randomised trial, The Lancet, vol.354, issue.9185, pp.795-802, 1999. ,
DOI : 10.1016/S0140-6736(99)07419-X
Method of feeding and transmission of HIV-1 from mothers to children by 15 months of age: prospective cohort study from Durban, South Africa, AIDS, vol.15, issue.3, pp.379-387, 2001. ,
DOI : 10.1097/00002030-200102160-00011
Infant feeding patterns and risks of death and hospitalization in the first half of infancy: multicentre cohort study, Bull World Health Organ, vol.83, pp.418-426, 2005. ,
Delayed Breastfeeding Initiation Increases Risk of Neonatal Mortality, PEDIATRICS, vol.117, issue.3, pp.380-386, 2006. ,
DOI : 10.1542/peds.2005-1496
Breast Health Problems Are Rare in Both HIV-Infected and HIV-Uninfected Women Who Receive Counseling and Support for Breast-Feeding in South Africa, Clinical Infectious Diseases, vol.45, issue.11, pp.1502-1510, 2007. ,
DOI : 10.1086/523320
URL : https://hal.archives-ouvertes.fr/inserm-00171008
The impact of breastmilk on infant and child health, Breastfeed Rev, vol.10, pp.5-18, 2002. ,
Breast-feeding and diarrheal morbidity, Pediatrics, vol.86, pp.874-882, 1990. ,
Breastfeeding practices in an area of high HIV prevalence in rural South Africa, Acta Paediatrica, vol.285, issue.6, pp.704-711, 2002. ,
DOI : 10.1111/j.1651-2227.2002.tb03306.x
Infant feeding practices in western Tanzania and Uganda: implications for infant feeding recommendations for HIV-infected mothers, Tropical Medicine and International Health, vol.58, issue.4, pp.477-485, 2004. ,
DOI : 10.1001/jama.283.9.1167
Intervention to promote exclusive breast-feeding for the first 6 months of life in a high HIV prevalence area, AIDS, vol.22, issue.7, pp.883-891, 2008. ,
DOI : 10.1097/QAD.0b013e3282f768de
Comparison of the effect of two systems for the promotion of exclusive breastfeeding, The Lancet, vol.366, issue.9491, pp.1094-1100, 2005. ,
DOI : 10.1016/S0140-6736(05)67421-1
Complementary feeding adequacy in relation to nutritional status among early weaned breastfed children who are born to HIV-infected mothers: ANRS 1201, Ditrame Plus Pediatrics, vol.117, pp.701-710, 1202. ,
URL : https://hal.archives-ouvertes.fr/inserm-00189790
A Large Outbreak of Diarrhea among Non-breastfed Children in Botswana, 2006?Implications for HIV Prevention Strategies and Child Health, The 14th Conference on Retroviruses and Opportunistic Infections, 2007. ,
The challenge of providing adequate infant nutrition following early breastfeeding cessation by HIV-positive, food-insecure Mozambican mothers, 2006. ,
Breastfeeding Plus Infant Zidovudine Prophylaxis for 6 Months vs Formula Feeding Plus Infant Zidovudine for 1 Month to Reduce Mother-to-Child HIV Transmission in Botswana, JAMA, vol.296, issue.7, pp.794-805, 2006. ,
DOI : 10.1001/jama.296.7.794
Rates of diarrhea associated with early weaning among infants in Kisumu, Kenya; The 14th Conference on Retroviruses and Opportunistic Infections, 2007. ,
Effects of Early, Abrupt Weaning on HIV-free Survival of Children in Zambia, New England Journal of Medicine, vol.359, issue.2, 2008. ,
DOI : 10.1056/NEJMoa073788
Antiretroviral Treatment and Prevention of Peripartum and Postnatal HIV Transmission in West Africa: Evaluation of a Two-Tiered Approach, PLoS Medicine, vol.346, issue.8, p.257, 2007. ,
DOI : 10.1371/journal.pmed.0040257.sd005
URL : https://hal.archives-ouvertes.fr/inserm-00170648
Prevention of Mother-to-Child Transmission of HIV-1 among Breastfeeding Mothers Using HAART: The Kisumu Breastfeeding Study, The 15th Conference on Retroviruses and Opportunistic Infections, 2003. ,
Flash-Heat Inactivation of HIV-1 in Human Milk, JAIDS Journal of Acquired Immune Deficiency Syndromes, vol.PAP, pp.318-323, 2007. ,
DOI : 10.1097/QAI.0b013e318074eeca
Pretoria pasteurisation: a potential method for the reduction of postnatal mother to child transmission of the human immunodeficiency virus, Journal of Tropical Pediatrics, vol.46, issue.4, pp.219-223, 2000. ,
DOI : 10.1093/tropej/46.4.219
Advances and research directions in the prevention of mother-to-child HIV-1 transmission, The Lancet, vol.355, issue.9222, pp.2237-2244, 2000. ,
DOI : 10.1016/S0140-6736(00)02415-6
Antiretroviral therapy among HIV-infected breastfeeding mothers: a promising strategy to prevent HIV postnatal transmission in Africa, Future HIV Therapy, vol.1, issue.1, pp.17-21, 2007. ,
DOI : 10.2217/17469600.1.1.17
Vaccines to prevent transmission of HIV-1 via breastmilk: scientific and logistical priorities, The Lancet, vol.368, issue.9534, pp.511-521, 2006. ,
DOI : 10.1016/S0140-6736(06)69159-9
A sustainable baby food support for HIV-1-infected mothers. The Kesho Bora study initiative in Bobo Dioulasso, Burkina Faso. The XVI International AIDS conference, 2006. ,
Extended Antiretroviral Prophylaxis to Reduce Breast-Milk HIV-1 Transmission, New England Journal of Medicine, vol.359, issue.2, pp.119-129, 2008. ,
DOI : 10.1056/NEJMoa0801941